Stephen M Beverley
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Explore the profile of Stephen M Beverley including associated specialties, affiliations and a list of published articles.
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160
Citations
5481
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Recent Articles
1.
Lye L, Dobson D, Beverley S, Tung M
J Microbiol Immunol Infect
. 2025 Jan;
PMID: 39884870
RNA interference (RNAi) is a biological process in which RNA molecules are involved in sequence-specific suppression of gene expression, via small RNA triggers derived from double-stranded RNA that can target...
2.
Ihedioha O, Marcarian H, Sivakoses A, Beverley S, McMahon-Pratt D, Bothwell A
Front Immunol
. 2024 Nov;
15:1473133.
PMID: 39502693
Background: Host-related factors highly regulate the increased circulation of neutrophils during infection. Platelet-derived Dickkopf-1 (DKK1) is established as a high-affinity ligand to LRP6. Recently, we demonstrated that DKK1 upregulates leukocyte-platelet...
3.
Heeren S, Maes I, Sanders M, Lye L, Adaui V, Arevalo J, et al.
Nat Commun
. 2023 Dec;
14(1):8343.
PMID: 38102141
Viruses are the most abundant biological entities on Earth and play a significant role in the evolution of many organisms and ecosystems. In pathogenic protozoa, the presence of viruses has...
4.
Ihedioha O, Sivakoses A, Beverley S, McMahon-Pratt D, Bothwell A
Front Immunol
. 2023 Oct;
14:1257046.
PMID: 37885890
Background: Platelets are rapidly deployed to infection sites and respond to pathogenic molecules via pattern recognition receptors (TLR, NLRP). Dickkopf1 (DKK1) is a quintessential Wnt antagonist produced by a variety...
5.
Serafim T, Iniguez E, Barletta A, Cecilio P, Doehl J, Short M, et al.
Nature
. 2023 Oct;
623(7985):149-156.
PMID: 37880367
Host factors that mediate Leishmania genetic exchange are not well defined. Here we demonstrate that natural IgM (IgMn) antibodies mediate parasite genetic exchange by inducing the transient formation of a...
6.
Haram C, Moitra S, Keane R, Kuhlmann F, Frankfater C, Hsu F, et al.
J Biol Chem
. 2023 Apr;
299(6):104745.
PMID: 37094699
The accessibility of sterols in mammalian cells to exogenous sterol-binding agents has been well-described previously, but sterol accessibility in distantly related protozoa is unclear. The human pathogen Leishmania major uses...
7.
Heeren S, Maes I, Sanders M, Lye L, Arevalo J, Llanos-Cuentas A, et al.
bioRxiv
. 2023 Mar;
PMID: 36993291
Viruses are the most abundant biological entities on Earth and play a significant role in the evolution of many organisms and ecosystems. In pathogenic protozoa, the presence of endosymbiotic viruses...
8.
Lye L, Owens K, Jang S, Marcus J, Brettmann E, Beverley S
Genes (Basel)
. 2023 Jan;
14(1).
PMID: 36672832
RNA interference (RNAi) is a powerful tool whose efficacy against a broad range of targets enables functional genetic tests individually or systematically. However, the RNAi pathway has been lost in...
9.
Cai C, OShea A, Eickhoff C, Guo H, Lewis W, Beverley S, et al.
Front Microbiol
. 2022 Dec;
13:1059115.
PMID: 36523834
Introduction: is the protozoan parasite causing Chagas disease, a Neglected Tropical Disease that affects 8 million people and causes 12,000 deaths per year, primarily because of cardiac pathology. Effective vaccination...
10.
Ferreira T, Inbar E, Shaik J, Jeffrey B, Ghosh K, Dobson D, et al.
mBio
. 2022 Nov;
13(6):e0285822.
PMID: 36394334
Genetic exchange between different strains in the sand fly vector has been experimentally demonstrated and is supported by population genetic studies. In nature, opportunities for interstrain mating are restricted to...