Stephen M Beverley
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Explore the profile of Stephen M Beverley including associated specialties, affiliations and a list of published articles.
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160
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5481
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Recent Articles
11.
Polanco G, Scott N, Lye L, Beverley S
Microbiol Spectr
. 2022 Nov;
10(6):e0305222.
PMID: 36394313
The trypanosomatid protozoan parasite has a significant impact on human health globally. Understanding the pathways associated with virulence within this significant pathogen is critical for identifying novel vaccination and chemotherapy...
12.
Mandell M, Beatty W, Beverley S
PLoS Negl Trop Dis
. 2022 Oct;
16(10):e0010893.
PMID: 36302046
Immediately following their deposition into the mammalian host by an infected sand fly vector, Leishmania parasites encounter and are engulfed by a variety of cell types. From there, parasites may...
13.
Kuhlmann F, Key P, Hickerson S, Turk J, Hsu F, Beverley S
J Biol Chem
. 2022 Sep;
298(11):102522.
PMID: 36162499
Many pathogens synthesize inositol phosphorylceramide (IPC) as the major sphingolipid (SL), differing from the mammalian host where sphingomyelin (SM) or more complex SLs predominate. The divergence between IPC synthase and...
14.
Jha B, Reverte M, Ronet C, Prevel F, Morgenthaler F, Desponds C, et al.
Front Cell Infect Microbiol
. 2022 Aug;
12:941860.
PMID: 36034709
The lymphatic system plays a crucial role in mounting immune response against intracellular pathogens, and recent studies have documented its role in facilitating tumor dissemination linked largely with cancer cells....
15.
Kopelyanskiy D, Desponds C, Prevel F, Rossi M, Migliorini R, Snaka T, et al.
Front Cell Infect Microbiol
. 2022 Aug;
12:944819.
PMID: 36034693
Inducible nitric oxide synthase (iNOS) is essential to the production of nitric oxide (NO), an efficient effector molecule against intracellular human pathogens such as protozoan parasites. Some strains of are...
16.
McDonald J, Jensen B, Sur A, Wong I, Beverley S, Myler P
Pathogens
. 2022 Aug;
11(8).
PMID: 36015053
Eukaryotes use histone variants and post-translation modifications (PTMs), as well as DNA base modifications, to regulate DNA replication/repair, chromosome condensation, and gene expression. Despite the unusual organization of their protein-coding...
17.
Song Y, Hou G, Diep J, Ooi Y, Akopyants N, Beverley S, et al.
Nucleic Acids Res
. 2021 Nov;
49(22):12706-12715.
PMID: 34791430
Endogenous retroviruses (ERVs) are subject to transcriptional repression in adult tissues, in part to prevent autoimmune responses. However, little is known about the epigenetic silencing of ERV expression. Here, we...
18.
Pant J, Samanovic M, Nelson M, Keceli M, Verdi J, Beverley S, et al.
PLoS Pathog
. 2021 Sep;
17(9):e1008768.
PMID: 34559857
Trypanosome Lytic Factor (TLF) is a primate-specific high-density lipoprotein (HDL) complex that, through the cation channel-forming protein apolipoprotein L-1 (APOL1), provides innate immunity to select kinetoplastid parasites. The immunoprotective effects...
19.
Warren W, Akopyants N, Dobson D, Hertz-Fowler C, Lye L, Myler P, et al.
Microbiol Resour Announc
. 2021 Sep;
10(35):e0054521.
PMID: 34472979
We report the high-quality draft assemblies and gene annotations for 13 species and/or strains of the protozoan parasite genera , , and , which span the phylogenetic diversity of the...
20.
Guo H, Damerow S, Penha L, Menzies S, Polanco G, Zegzouti H, et al.
Proc Natl Acad Sci U S A
. 2021 Aug;
118(33).
PMID: 34385330
Glycoconjugates play major roles in the infectious cycle of the trypanosomatid parasite While GDP-Fucose synthesis is essential, fucosylated glycoconjugates have not been reported in [H. Guo et al., 292, 10696-10708...