Stephen J Lockett
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Explore the profile of Stephen J Lockett including associated specialties, affiliations and a list of published articles.
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50
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1727
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Recent Articles
11.
McGinity C, Palmieri E, Somasundaram V, Bhattacharyya D, Ridnour L, Cheng R, et al.
Int J Mol Sci
. 2021 Jul;
22(13).
PMID: 34209132
The metabolic requirements and functions of cancer and normal tissues are vastly different. Due to the rapid growth of cancer cells in the tumor microenvironment, distorted vasculature is commonly observed,...
12.
Sjoberg H, Philippou Y, Magnussen A, Tullis I, Bridges E, Chatrian A, et al.
Br J Cancer
. 2021 Jun;
125(4):534-546.
PMID: 34155340
Background: There is a need to improve the treatment of prostate cancer (PCa) and reduce treatment side effects. Vascular-targeted photodynamic therapy (VTP) is a focal therapy for low-risk low-volume localised...
13.
Gilmore A, Flaherty S, Somasundaram V, Scheiblin D, Lockett S, Wink D, et al.
Commun Biol
. 2021 Apr;
4(1):477.
PMID: 33859337
The tumor microenvironment (TME) is multi-cellular, spatially heterogenous, and contains cell-generated gradients of soluble molecules. Current cell-based model systems lack this complexity or are difficult to interrogate microscopically. We present...
14.
Chrisafis G, Wang T, Moissoglu K, Gasparski A, Ng Y, Weigert R, et al.
Proc Natl Acad Sci U S A
. 2020 Oct;
117(44):27423-27434.
PMID: 33060293
Localization of RNAs at protrusive regions of cells is important for single-cell migration on two-dimensional surfaces. Protrusion-enriched RNAs encode factors linked to cancer progression, such as the RAB13 GTPase and...
15.
Philippou Y, Sjoberg H, Murphy E, Alyacoubi S, Jones K, Gordon-Weeks A, et al.
Br J Cancer
. 2020 Jul;
123(7):1089-1100.
PMID: 32641865
Background: Radiotherapy enhances innate and adaptive anti-tumour immunity. It is unclear whether this effect may be harnessed by combining immunotherapy with radiotherapy fractions used to treat prostate cancer. We investigated...
16.
Somasundaram V, Gilmore A, Basudhar D, Palmieri E, Scheiblin D, Heinz W, et al.
Redox Biol
. 2019 Nov;
28:101354.
PMID: 31683257
The role of nitric oxide (NO) in cancer progression has largely been studied in the context of tumor NOS2 expression. However, pro- versus anti-tumor signaling is also affected by tumor...
17.
Matarlo J, Krumpe L, Heinz W, Oh D, Shenoy S, Thomas C, et al.
Cell Chem Biol
. 2019 Jun;
26(8):1133-1142.e4.
PMID: 31155509
Identification of RNA-interacting pharmacophores could provide chemical probes and, potentially, small molecules for RNA-based therapeutics. Using a high-throughput differential scanning fluorimetry assay, we identified small-molecule natural products with the capacity...
18.
Kulkarni R, Briney C, Crooks D, Bergholtz S, Mushti C, Lockett S, et al.
Chembiochem
. 2018 Oct;
20(3):360-365.
PMID: 30358041
Dysregulated metabolism can fuel cancer by altering the production of bioenergetic building blocks and directly stimulating oncogenic gene-expression programs. However, relatively few optical methods for the direct study of metabolites...
19.
Basudhar D, Bharadwaj G, Somasundaram V, Cheng R, Ridnour L, Fujita M, et al.
Br J Pharmacol
. 2018 Aug;
176(2):155-176.
PMID: 30152521
Recent findings suggest that co-expression of NOS2 and COX2 is a strong prognostic indicator in triple-negative breast cancer patients. These two key inflammation-associated enzymes are responsible for the biosynthesis of...
20.
Basudhar D, Glynn S, Greer M, Somasundaram V, No J, Scheiblin D, et al.
Proc Natl Acad Sci U S A
. 2017 Nov;
114(49):13030-13035.
PMID: 29087320
Proinflammatory signaling pathways are commonly up-regulated in breast cancer. In estrogen receptor-negative (ER) and triple-negative breast cancer (TNBC), nitric oxide synthase-2 (NOS2) and cyclooxygenase-2 (COX2) have been described as independent...