Stephen J Lockett
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Explore the profile of Stephen J Lockett including associated specialties, affiliations and a list of published articles.
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50
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1727
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Recent Articles
1.
Ridnour L, Heinz W, Cheng R, Wink A, Kedei N, Pore M, et al.
Cancer Res Commun
. 2024 Oct;
4(10):2766-2782.
PMID: 39356141
This work identifies CD8-NOS2+COX2+ and CD8-NOS2-COX2+ unique cellular neighborhoods that drive the tumor immune spatial architecture of CD8+ T cells predictive of clinical outcome and can be targeted with clinically...
2.
Kundu M, Greer Y, Lobanov A, Ridnour L, Donahue R, Ng Y, et al.
bioRxiv
. 2024 Aug;
PMID: 39091795
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potential cancer therapeutic that induces apoptosis in cancer cells while sparing the non-malignant cells in preclinical models. However, its efficacy in clinical...
3.
Ridnour L, Cheng R, Kedei N, Somasundaram V, Bhattacharyya D, Basudhar D, et al.
JCI Insight
. 2024 Jun;
9(12).
PMID: 38912586
Immune therapy is the new frontier of cancer treatment. Therapeutic radiation is a known inducer of immune response and can be limited by immunosuppressive mediators including cyclooxygenase-2 (COX2) that is...
4.
Coutinho L, Femino E, Gonzalez A, Moffat R, Heinz W, Cheng R, et al.
Int J Mol Sci
. 2024 Jun;
25(11).
PMID: 38892290
Nitric oxide (NO) and reactive nitrogen species (RNS) exert profound biological impacts dictated by their chemistry. Understanding their spatial distribution is essential for deciphering their roles in diverse biological processes....
5.
Ridnour L, Cheng R, Heinz W, Pore M, Gonzalez A, Femino E, et al.
bioRxiv
. 2024 Jan;
PMID: 38187660
Multiple immunosuppressive mechanisms exist in the tumor microenvironment that drive poor outcomes and decrease treatment efficacy. The co-expression of NOS2 and COX2 is a strong predictor of poor prognosis in...
6.
Ridnour L, Heinz W, Cheng R, Wink A, Kedei N, Pore M, et al.
bioRxiv
. 2024 Jan;
PMID: 38187532
Estrogen receptor-negative (ER-) breast cancer is an aggressive breast cancer subtype with limited therapeutic options. Upregulated expression of both inducible nitric oxide synthase (NOS2) and cyclo-oxygenase (COX2) in breast tumors...
7.
Cheng R, Ridnour L, Wink A, Gonzalez A, Femino E, Rittscher H, et al.
Cell Death Dis
. 2023 May;
14(5):319.
PMID: 37169743
A strong correlation between NOS2 and COX2 tumor expression and poor clinical outcomes in ER breast cancer has been established. However, the mechanisms of tumor induction of these enzymes are...
8.
Cheng R, Ridnour L, Wink A, Gonzalez A, Femino E, Rittscher H, et al.
bioRxiv
. 2023 Apr;
PMID: 37066331
A strong correlation between NOS2 and COX2 tumor expression and poor clinical outcomes in ER-breast cancer has been established. However, mechanisms of tumor induction of these enzymes are unclear. Analysis...
9.
Moissoglu K, Lockett S, Mili S
Methods Mol Biol
. 2023 Jan;
2608:263-280.
PMID: 36653713
Localization of mRNAs at the front of migrating cells is a widely used mechanism that functionally supports efficient cell movement. It is observed in single cells on two-dimensional surfaces, as...
10.
Somasundaram V, Ridnour L, Cheng R, Walke A, Kedei N, Bhattacharyya D, et al.
Redox Biol
. 2022 Nov;
58:102529.
PMID: 36375380
Antitumor immune polarization is a key predictor of clinical outcomes to cancer therapy. An emerging concept influencing clinical outcome involves the spatial location of CD8 T cells, within the tumor....