Stephen F Traynelis
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Explore the profile of Stephen F Traynelis including associated specialties, affiliations and a list of published articles.
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205
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9261
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Recent Articles
1.
Kang H, Epstein M, Banke T, Perszyk R, Simorowski N, Paladugu S, et al.
Neuron
. 2025 Feb;
PMID: 39954679
Discrete activation of N-methyl-D-aspartate receptor (NMDAR) subtypes by glutamate and the co-agonist glycine is fundamental to neuroplasticity. A distinct variant, the tri-heteromeric receptor, comprising glycine-binding GluN1 and two types of...
2.
Wang H, Dingledine R, Myers S, Traynelis S, Fang C, Tan Y, et al.
J Pharmacol Exp Ther
. 2025 Feb;
392(1):100046.
PMID: 39892986
Aneurysmal subarachnoid hemorrhage (SAH) may be associated with cerebral vasospasm, which can lead to delayed cerebral ischemia, infarction, and worsened functional outcomes. The delayed nature of cerebral ischemia secondary to...
3.
Camp C, Banke T, Xing H, Yu K, Perszyk R, Epplin M, et al.
bioRxiv
. 2024 Nov;
PMID: 39574703
Significance Statement: Interneuron dysfunction and diminished GABAergic inhibition in neocortical and hippocampal circuits remains a prominent molecular hypothesis for neuropsychiatric diseases including anxiety, depression, and schizophrenia. Pharmacological agents that boost...
4.
Montanucci L, Brunger T, Bhattarai N, Bosselmann C, Kim S, Allen J, et al.
Hum Mol Genet
. 2024 Nov;
34(2):128-139.
PMID: 39535073
Genetic variants in the genes GRIN1, GRIN2A, GRIN2B, and GRIN2D, which encode subunits of the N-methyl-D-aspartate receptor (NMDAR), have been associated with severe and heterogeneous neurologic and neurodevelopmental disorders, including...
5.
Ullman E, Perszyk R, Paladugu S, Fritzemeier R, Akins N, Jacobs L, et al.
Mol Pharmacol
. 2024 Oct;
106(6):334-353.
PMID: 39443157
N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors that mediate a slow, Ca-permeable component of excitatory neurotransmission. Modulation of NMDAR function has the potential for disease modification as NMDAR dysfunction has...
6.
Sullivan M, Tidball P, Yan Y, Intson K, Chen W, Xu Y, et al.
bioRxiv
. 2024 Sep;
PMID: 39229143
Objective: -related neurodevelopmental disorder ( -NDD) is characterized by clinically significant variation in the gene, which encodes the obligatory GluN1 subunit of N-methyl-D-aspartate receptors (NMDARs). The identified p.Tyr647Ser (Y647S) variant...
7.
Chou T, Epstein M, Fritzemeier R, Akins N, Paladugu S, Ullman E, et al.
Nature
. 2024 Jul;
632(8023):209-217.
PMID: 39085540
Glutamate transmission and activation of ionotropic glutamate receptors are the fundamental means by which neurons control their excitability and neuroplasticity. The N-methyl-D-aspartate receptor (NMDAR) is unique among all ligand-gated channels,...
8.
Roh W, Yoo J, Dravid S, Mannaioni G, Krizman E, Wahl P, et al.
Glia
. 2024 Jun;
72(9):1707-1724.
PMID: 38864289
Astrocytes play an essential role in regulating synaptic transmission. This study describes a novel form of modulation of excitatory synaptic transmission in the mouse hippocampus by astrocytic G-protein-coupled receptors (GPCRs)....
9.
Montanucci L, Brunger T, Bhattarai N, Bosselmann C, Kim S, Allen J, et al.
medRxiv
. 2024 May;
PMID: 38766179
Genetic variants in genes , , , and , which encode subunits of the N-methyl-D-aspartate receptor (NMDAR), have been associated with severe and heterogeneous neurologic diseases. Missense variants in these...
10.
Yi F, Traynelis S, Hansen K
Methods Mol Biol
. 2024 May;
2799:55-77.
PMID: 38727903
NMDA-type ionotropic glutamate receptors are critically involved in many brain functions and are implicated in a variety of brain disorders. Seven NMDA receptor subunits exist (GluN1, GluN2A-D, and GluN3A-B) that...