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Stephen English

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Articles 12
Citations 54
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Recent Articles
1.
Lee C, Oh D, Tang Y, Yi P, Bashir M, English S, et al.
Clin Pharmacol Drug Dev . 2023 May; 12(6):553-571. PMID: 37132407
Etrasimod (APD334) is an investigational, once-daily, oral, selective sphingosine 1-phosphate receptor 1,4,5 modulator (S1P ) in development for treatment of various immune-mediated inflammatory disorders. The disposition and mass balance of...
2.
Dumitrascu O, English S, Alhayek N, Pahl E, Nord C, Vanderhye V, et al.
Telemed J E Health . 2023 Mar; 29(11):1738-1743. PMID: 36912816
3.
Fitch W, Smith S, Saporito M, Busse G, Zhang M, Ren J, et al.
Drug Metab Dispos . 2023 Mar; 51(6):753-763. PMID: 36863866
The human pharmacokinetics, metabolism, and excretion of [C]-ganaxolone (GNX) were characterized in healthy male subjects ( = 8) following a single 300-mg (150 Ci) oral dose. GNX exhibited a short...
4.
Ward R, Graff-Radford J, Ponamgi S, English S, Meskill A, Challa A, et al.
Proc (Bayl Univ Med Cent) . 2022 Mar; 35(2):162-167. PMID: 35261442
Atrial fibrillation (AF) and cerebral amyloid angiopathy (CAA) present risks of ischemic stroke and intracerebral hemorrhage (ICH). Vitamin K antagonist use is associated with fluctuations in international normalized ratio (INR),...
5.
Landzberg D, English S, Frankel M, Navalkele D
J Stroke Cerebrovasc Dis . 2020 Dec; 30(2):105520. PMID: 33310594
Background: Ticagrelor is a novel antiplatelet agent that is frequently used for secondary prevention in coronary artery disease and has emerging evidence in stroke after the recent results of SOCRATES...
6.
Ward R, Ponamgi S, DeSimone C, English S, Hodge D, Slusser J, et al.
Mayo Clin Proc . 2020 Aug; 95(10):2090-2098. PMID: 32829908
Objective: To determine the utility of the HAS-BLED (Hypertension, Abnormal renal/liver function, Stroke, Bleeding history or predisposition, Labile international normalized ratio, Elderly, Drugs/alcohol concomitantly) and CHADS-VASc (Congestive heart failure, Hypertension,...
7.
Ponamgi S, Ward R, DeSimone C, English S, Hodge D, Slusser J, et al.
J Am Heart Assoc . 2020 Jul; 9(15):e016893. PMID: 32715895
Background Intracerebral hemorrhage (ICH) risk is higher in elderly patients with atrial fibrillation on antithrombotic therapy as well as those with cerebral amyloid angiopathy (CAA). We investigated if mortality among...
8.
Boof M, Van Lier J, English S, Fischer H, Ufer M, Dingemanse J
Xenobiotica . 2020 Feb; 50(8):947-956. PMID: 32105166
Cenerimod is a sphingosine-1-phosphate 1 receptor modulator under development for treatment of systemic lupus erythematosus.This single-centre, open-label, single-dose study investigated the mass balance and excretion routes and aimed at identifying...
9.
Vishwanathan K, So K, Thomas K, Bramley A, English S, Collier J
Clin Pharmacol Drug Dev . 2018 Apr; 8(2):198-207. PMID: 29683562
Osimertinib is a third-generation, central nervous system-active, epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) selective for EGFR-TKI sensitizing and T790M resistance mutations. This phase 1, open-label study (NCT02491944) investigated absolute...
10.
Goldstein E, Cannistraro R, English S, Vazquez Do Campo R, Eidelman B
J Stroke Cerebrovasc Dis . 2017 Nov; 27(2):e34-e35. PMID: 29102392
Limb-shaking transient ischemic attacks (LSTIAs) are a phenomenon that occurs due to transient hypoperfusion to a cerebral motor territory with a chronically outstripped autoregulatory vascular reserve. First described in 1962...