Stephen E Girardin
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Explore the profile of Stephen E Girardin including associated specialties, affiliations and a list of published articles.
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174
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16278
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Recent Articles
1.
Lamorte S, Quevedo R, Jin R, Neufeld L, Liu Z, Ciudad M, et al.
Cancer Cell
. 2025 Mar;
PMID: 40054466
Apoptotic cells are immunosuppressive, creating a barrier in cancer treatment. Thus, we investigated immune responses to dying tumor cells after therapy in the tumor draining lymph node (TDLN). A key...
2.
Winsor N, Bayer G, Singh O, Chan J, Li L, Lieng B, et al.
Cell Host Microbe
. 2025 Mar;
33(3):388-407.e9.
PMID: 40043701
Intestinal protists are detected by the host innate immune system through mechanisms that remain poorly understood. Here, we demonstrate that Tritrichomonas protozoa induce thickening of the colonic mucus in an...
3.
Meade J, Stuart S, Neiman-Zenevich J, Krustev C, Girardin S, Mogridge J
Commun Biol
. 2024 Sep;
7(1):1164.
PMID: 39289441
Cleavage of the innate immune receptor NLRP1B by various microbial proteases causes the proteasomal degradation of its N-terminal fragment and the subsequent release of a C-terminal fragment that forms an...
4.
Mazzone R, Winsor N, Li L, Barry K, Ranger A, Goyal S, et al.
Microbes Infect
. 2024 Jul;
26(8):105398.
PMID: 39047896
The intestinal mucosa must balance tolerance to commensal microbes and luminal antigens with rapid detection of enteric pathogens in order to maintain homeostasis. This balance is facilitated through the regulation...
5.
Pradeu T, Thomma B, Girardin S, Lemaitre B
Immunity
. 2024 Apr;
57(4):613-631.
PMID: 38599162
While largely neglected over decades during which adaptive immunity captured most of the attention, innate immune mechanisms have now become central to our understanding of immunology. Innate immunity provides the...
6.
Bi P, Killackey S, Schweizer L, Arnoult D, Philpott D, Girardin S
Commun Biol
. 2024 Mar;
7(1):391.
PMID: 38555279
Mitochondrial stress inducers such as carbonyl cyanide m-chlorophenyl hydrazone (CCCP) and oligomycin trigger the DELE1-HRI branch of the integrated stress response (ISR) pathway. Previous studies performed using epitope-tagged DELE1 showed...
7.
Liu Y, Kors L, Butter L, Stokman G, Claessen N, Zuurbier C, et al.
Cells
. 2024 Jan;
13(1).
PMID: 38201227
Background: Chronic kidney disease often leads to kidney dysfunction due to renal fibrosis, regardless of the initial cause of kidney damage. Macrophages are crucial players in the progression of renal...
8.
Liuu S, Nepelska M, Pfister H, Gamelas Magalhaes J, Chevalier G, Strozzi F, et al.
Proc Natl Acad Sci U S A
. 2023 Dec;
120(52):e2306863120.
PMID: 38127978
The gut microbiota is a considerable source of biologically active compounds that can promote intestinal homeostasis and improve immune responses. Here, we used large expression libraries of cloned metagenomic DNA...
9.
Bi P, Killackey S, Schweizer L, Girardin S
Biomed J
. 2023 Aug;
47(1):100635.
PMID: 37574163
NLRX1 is a member of the of the Nod-like receptor (NLR) family, and it represents a unique pattern recognition molecule (PRM) as it localizes to the mitochondrial matrix in resting...
10.
Foerster E, Tsang D, Goyal S, Robertson S, Robert L, Maughan H, et al.
Mucosal Immunol
. 2023 Feb;
16(2):135-152.
PMID: 36792009
The breakdown of the intestinal mucosal barrier is thought to underlie the progression to Crohn disease (CD), whereby numerous risk factors contribute. For example, a genetic polymorphism of the autophagy...