Stephen C Parnell
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Explore the profile of Stephen C Parnell including associated specialties, affiliations and a list of published articles.
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16
Citations
386
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Recent Articles
1.
Maser R, Calvet J, Parnell S
Front Mol Biosci
. 2022 Nov;
9:1035507.
PMID: 36406261
Polycystin-1 (PC1) is an 11-transmembrane (TM) domain-containing protein encoded by the gene, the most frequently mutated gene leading to autosomal dominant polycystic kidney disease (ADPKD). This large (> 462 kDal)...
2.
Parnell S, Raman A, Zhang Y, Daniel E, Dai Y, Khanna A, et al.
Kidney Int
. 2022 Jun;
102(5):1103-1114.
PMID: 35760151
Polycystic kidney disease (PKD) is characterized by the formation and progressive enlargement of fluid-filled cysts due to abnormal cell proliferation. Cyclic AMP agonists, including arginine vasopressin, stimulate ERK-dependent proliferation of...
3.
Riddle H, Zhang S, Qian F, Williams Jr J, Stubbs J, Rowe P, et al.
Am J Physiol Renal Physiol
. 2022 Mar;
323(1):F59-F68.
PMID: 35343849
Individuals with autosomal dominant polycystic kidney disease have a higher incidence of stone formation than the general population. However, there are no cystic animal models known to develop stones. Cystic...
4.
Lea W, McGreal K, Sharma M, Parnell S, Zelenchuk L, Charlesworth M, et al.
Sci Rep
. 2020 Feb;
10(1):1500.
PMID: 32001768
The polycystin-1 (PC1), polycystin-2 (PC2) and fibrocystin proteins, the respective products of the PKD1, PKD2 and PKHD1 genes, are abundant in urinary exosome-like vesicles (ELVs) where they form the polycystin...
5.
Raman A, Parnell S, Zhang Y, Reif G, Dai Y, Khanna A, et al.
Am J Physiol Renal Physiol
. 2018 Oct;
315(6):F1695-F1707.
PMID: 30332313
In polycystic kidney disease (PKD), persistent activation of cell proliferation and matrix production contributes to cyst growth and fibrosis, leading to progressive deterioration of renal function. Previously, we showed that...
6.
Lea W, Parnell S, Wallace D, Calvet J, Zelenchuk L, Alvarez N, et al.
J Am Soc Nephrol
. 2018 Sep;
29(10):2482-2492.
PMID: 30185468
Background: The major form of autosomal dominant polycystic kidney disease is caused by heterozygous mutations in , the gene that encodes polycystin-1 (PC1). Unlike genes in the mouse and most...
7.
Parnell S, Magenheimer B, Maser R, Pavlov T, Havens M, Hastings M, et al.
Hum Mol Genet
. 2018 Jun;
27(19):3313-3324.
PMID: 29931260
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the growth of renal cysts that ultimately destroy kidney function. Mutations in the PKD1 and PKD2 genes cause ADPKD. Their protein...
8.
Raman A, Reif G, Dai Y, Khanna A, Li X, Astleford L, et al.
J Am Soc Nephrol
. 2017 May;
28(9):2708-2719.
PMID: 28522687
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by innumerous fluid-filled cysts and progressive deterioration of renal function. Previously, we showed that periostin, a matricellular protein involved in tissue repair,...
9.
Wallace D, White C, Savinkova L, Nivens E, Reif G, Pinto C, et al.
Kidney Int
. 2013 Nov;
85(4):845-54.
PMID: 24284511
In renal cystic diseases, sustained enlargement of fluid-filled cysts is associated with severe interstitial fibrosis and progressive loss of functioning nephrons. Periostin, a matricellular protein, is highly overexpressed in cyst-lining...
10.
Hao N, Yildirim N, Nagiec M, Parnell S, Errede B, Dohlman H, et al.
Mol Biol Cell
. 2012 Aug;
23(19):3899-910.
PMID: 22875986
Different environmental stimuli often use the same set of signaling proteins to achieve very different physiological outcomes. The mating and invasive growth pathways in yeast each employ a mitogen-activated protein...