Stephen C-T Lam
Overview
Explore the profile of Stephen C-T Lam including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
16
Citations
903
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Shen B, Zhao X, OBrien K, Stojanovic-Terpo A, Delaney M, Kim K, et al.
Nature
. 2013 Oct;
503(7474):131-5.
PMID: 24162846
Integrins have a critical role in thrombosis and haemostasis. Antagonists of the platelet integrin αIIbβ3 are potent anti-thrombotic drugs, but also have the life-threatening adverse effect of causing bleeding. It...
2.
Gong H, Shen B, Flevaris P, Chow C, Lam S, Voyno-Yasenetskaya T, et al.
Science
. 2010 Jan;
327(5963):340-3.
PMID: 20075254
Integrins mediate cell adhesion to the extracellular matrix and transmit signals within the cell that stimulate cell spreading, retraction, migration, and proliferation. The mechanism of integrin outside-in signaling has been...
3.
Srinivasan S, Mir F, Huang J, Khasawneh F, Lam S, Le Breton G
J Biol Chem
. 2009 Apr;
284(24):16108-16117.
PMID: 19346255
ADP plays an integral role in the process of hemostasis by signaling through two platelet G-protein-coupled receptors, P2Y1 and P2Y12. The recent use of antagonists against these two receptors has...
4.
Podolnikova N, OToole T, Haas T, Lam S, Fox J, Ugarova T
Biochemistry
. 2009 Jan;
48(3):617-29.
PMID: 19117493
Integrin alpha(IIb)beta(3) plays a pivotal role in hemostasis and thrombosis by mediating adhesive interactions of platelets. Binding of alpha(IIb)beta(3) to its physiological ligands, immobilized fibrinogen and fibrin, induces outside-in signaling...
5.
Yakubenko V, Belevych N, Mishchuk D, Schurin A, Lam S, Ugarova T
Exp Cell Res
. 2008 Jul;
314(14):2569-78.
PMID: 18621369
Integrin alpha(D)beta(2) (CD11d/CD18) is a multiligand macrophage receptor with recognition specificity identical to that of the major myeloid cell-specific integrin alpha(M)beta(2) (CD11b/CD18, Mac-1). Despite its prominent upregulation on inflammatory macrophages,...
6.
Xing B, Thuppal S, Jedsadayanmata A, Du X, Lam S
FEBS Lett
. 2006 Mar;
580(8):2027-32.
PMID: 16546176
Talin mediates integrin signaling by binding to integrin cytoplasmic tails through its FERM domain which consists of F1, F2 and F3 subdomains. TA205, an anti-talin monoclonal antibody, disrupts actin stress...
7.
Yuan W, Leisner T, McFadden A, Wang Z, Larson M, Clark S, et al.
J Cell Biol
. 2006 Jan;
172(2):169-75.
PMID: 16418530
In response to agonist stimulation, the alphaIIbbeta3 integrin on platelets is converted to an active conformation that binds fibrinogen and mediates platelet aggregation. This process contributes to both normal hemostasis...
8.
Leu S, Chen N, Chen C, Todorovic V, Bai T, Juric V, et al.
J Biol Chem
. 2004 Aug;
279(42):44177-87.
PMID: 15322081
The matricellular protein CCN1 (CYR61) regulates multiple cellular processes and plays essential roles in embryonic vascular development. A ligand of several integrin receptors, CCN1 acts through integrin alpha6beta1 and heparan...
9.
Chen N, Leu S, Todorovic V, Lam S, Lau L
J Biol Chem
. 2004 Aug;
279(42):44166-76.
PMID: 15308622
CCN1 (CYR61) is a matricellular inducer of angiogenesis essential for successful vascular development. Though devoid of the canonical RGD sequence motif recognized by some integrins, CCN1 binds to, and functions...
10.
Xi X, Bodnar R, Li Z, Lam S, Du X
J Cell Biol
. 2003 Jul;
162(2):329-39.
PMID: 12860973
Bidirectional signaling of integrin alphaIIbbeta3 requires the beta3 cytoplasmic domain. To determine the sequence in the beta3 cytoplasmic domain that is critical to integrin signaling, cell lines were established that...