Stephano Spano Mello
Overview
Explore the profile of Stephano Spano Mello including associated specialties, affiliations and a list of published articles.
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10
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1080
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Recent Articles
1.
Valente L, Tarangelo A, Li A, Naciri M, Raj N, Boutelle A, et al.
J Cell Biol
. 2020 Sep;
219(11).
PMID: 32886745
The mechanisms by which TP53, the most frequently mutated gene in human cancer, suppresses tumorigenesis remain unclear. p53 modulates various cellular processes, such as apoptosis and proliferation, which has led...
2.
Mello S, Attardi L
Cell Cycle
. 2018 Jun;
17(13):1527-1535.
PMID: 29895201
Although the p53 transcription factor has a well-established role in tumor suppression, little is known about how the non-coding targets of p53 mediate its tumor suppression function. Analysis of ncRNAs...
3.
Bieging K, Mello S, Attardi L
Nat Rev Cancer
. 2014 Apr;
14(5):359-70.
PMID: 24739573
p53 is a crucial tumour suppressor that responds to diverse stress signals by orchestrating specific cellular responses, including transient cell cycle arrest, cellular senescence and apoptosis, which are all processes...
4.
Broz D, Mello S, Bieging K, Jiang D, Dusek R, Brady C, et al.
Genes Dev
. 2013 May;
27(9):1016-31.
PMID: 23651856
The mechanisms by which the p53 tumor suppressor acts remain incompletely understood. To gain new insights into p53 biology, we used high-throughput sequencing to analyze global p53 transcriptional networks in...
5.
Carminati P, Mello S, Fachin A, Junta C, Sandrin-Garcia P, Carlotti C, et al.
Genet Mol Biol
. 2011 Jun;
33(1):159-68.
PMID: 21637621
Gliomas are the most common tumors in the central nervous system, the average survival time of patients with glioblastoma multiforme being about 1 year from diagnosis, in spite of harsh...
6.
Gitai D, Fachin A, Mello S, Elias C, Bittencourt J, Leite J, et al.
Brain Res
. 2010 Oct;
1367:114-21.
PMID: 20974111
The aim of this study was to identify molecular pathways involved in audiogenic seizures in the epilepsy-prone Wistar Audiogenic Rat (WAR). For this, we used a suppression-subtractive hybridization (SSH) library...
7.
Fachin A, Mello S, Sandrin-Garcia P, Junta C, Ghilardi-Netto T, Donadi E, et al.
J Radiat Res
. 2009 Feb;
50(1):61-71.
PMID: 19218781
Ionizing radiation (IR) imposes risks to human health and the environment. IR at low doses and low dose rates has the potency to initiate carcinogenesis. Genotoxic environmental agents such as...
8.
Junta C, Sandrin-Garcia P, Fachin-Saltoratto A, Mello S, Oliveira R, Rassi D, et al.
Immunology
. 2009 Feb;
127(3):365-72.
PMID: 19191904
This study aimed to evaluate the association between the differential gene expression profiling of peripheral blood mononuclear cells of rheumatoid arthritis patients with their immunogenetic (human leucocyte antigen shared-epitope, HLA-SE),...
9.
Zarate-Blades C, Bonato V, Silveira E, Paula M, Junta C, Sandrin-Garcia P, et al.
J Gene Med
. 2008 Nov;
11(1):66-78.
PMID: 19035575
Background: The continued increase in tuberculosis (TB) rates and the appearance of extremely resistant Mycobacterium tuberculosis strains (XDR-TB) worldwide are some of the great problems of public health. In this...
10.
Pereira E, Tamia-Ferreira M, Cardoso R, Mello S, Sakamoto-Hojo E, Passos G, et al.
Immunology
. 2004 Aug;
113(1):99-105.
PMID: 15312140
To evaluate the T-cell large-scale differential gene expression in systemic lupus erythematosus (SLE) patients presenting with glomerulonephritis we studied SLE patients before and after immunosuppressive treatment. Large-scale gene expression of...