Stephanie Totten
Overview
Explore the profile of Stephanie Totten including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
131
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0
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Recent Articles
1.
Ambekar P, Wang Y, Khokhlova T, Khokhlova T, Thomas G, Thomas G, et al.
IEEE Trans Ultrason Ferroelectr Freq Control
. 2024 Oct;
71:1868-1878.
PMID: 39383065
Large abscesses are walled-off collections of pus and bacteria that often do not respond to antibiotic therapy. Standard of care involves percutaneous placement of indwelling catheter(s) for drainage, a long...
2.
Song M, Sapozhnikov O, Khokhlova V, Son H, Totten S, Wang Y, et al.
Sci Rep
. 2024 Sep;
14(1):22295.
PMID: 39333771
Pulsed high-intensity focused ultrasound (pHIFU) has the capability to induce de novo cavitation bubbles, offering potential applications for enhancing drug delivery and modulating tissue microenvironments. However, imaging and monitoring these...
3.
Ponomarchuk E, Thomas G, Song M, Wang Y, Totten S, Schade G, et al.
Ultrasound Med Biol
. 2024 Sep;
50(12):1936-1944.
PMID: 39317625
Objective: In the context of developing boiling histotripsy (BH) as a potential clinical approach for non-invasive mechanical ablation of kidney tumors, the concept of BH dose (BHD) was quantitatively investigated...
4.
Lewis K, La Selva R, Maldonado E, Annis M, Najyb O, Cepeda Canedo E, et al.
Redox Biol
. 2024 Jan;
70:103028.
PMID: 38211442
Significant efforts have focused on identifying targetable genetic drivers that support the growth of solid tumors and/or increase metastatic ability. During tumor development and progression to metastatic disease, physiological and...
5.
Ambekar P, Wang Y, Khokhlova T, Bruce M, Leotta D, Totten S, et al.
Ultrasound Med Biol
. 2023 Sep;
49(12):2451-2458.
PMID: 37718123
Objective: Bacterial loads can be effectively reduced using cavitation-mediated focused ultrasound, or histotripsy. In this study, gram-negative bacteria (Escherichia coli) in suspension were used as model bacteria to evaluate the...
6.
Khokhlova T, Wang Y, Son H, Totten S, Whang S, Hwang J
Ultrasonics
. 2023 Apr;
132:106993.
PMID: 37099937
Pulsed high intensity focused ultrasound (pHIFU) is a non-invasive method that allows to permeabilize pancreatic tumors through inertial cavitation and thereby increase the concentration of systemically administered drug. In this...
7.
Vohra R, Wang Y, Son H, Totten S, Arora A, Maxwell A, et al.
Cancers (Basel)
. 2022 Feb;
14(4).
PMID: 35205746
Pancreatic ductal adenocarcinomas are characterized by a complex and robust tumor microenvironment (TME) consisting of fibrotic tissue, excessive levels of hyaluronan (HA), and immune cells. We utilized quantitative multi-parametric magnetic...
8.
Keller S, Wang Y, Totten S, Yeung R, Averkiou M
Ultrasound Med Biol
. 2021 Aug;
47(11):3211-3220.
PMID: 34362584
Ultrasound and microbubbles are useful for both diagnostic imaging and targeted drug delivery, making them ideal conduits for theranostic interventions. Recent reports have indicated the preclinical success of microbubble cavitation...
9.
Maxwell A, Hunter C, Cunitz B, Kreider W, Totten S, Wang Y
Ultrasound Med Biol
. 2021 Jun;
47(8):2286-2295.
PMID: 34078545
Burst wave lithotripsy (BWL) is a technology under clinical investigation for non-invasive fragmentation of urinary stones. Under certain ranges of ultrasound exposure parameters, this technology can cause cavitation in tissue...
10.
Haddad N, Weeks A, Robert A, Totten S
Can Commun Dis Rep
. 2021 Mar;
47(1):77-86.
PMID: 33679250
Background: Human immunodeficiency virus (HIV) is a global public health issue. HIV has been nationally notifiable in Canada since 1985. The Public Health Agency of Canada (PHAC) monitors trends in...