Stephanie Gon
Overview
Explore the profile of Stephanie Gon including associated specialties, affiliations and a list of published articles.
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17
Citations
508
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0
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Recent Articles
1.
Berti M, Teloni F, Mijic S, Ursich S, Fuchs J, Palumbieri M, et al.
Nat Commun
. 2020 Jul;
11(1):3531.
PMID: 32669601
Homologous recombination (HR) factors were recently implicated in DNA replication fork remodeling and protection. While maintaining genome stability, HR-mediated fork remodeling promotes cancer chemoresistance, by as-yet elusive mechanisms. Five HR...
2.
Garcin E, Gon S, Sullivan M, Brunette G, De Cian A, Concordet J, et al.
PLoS Genet
. 2019 Oct;
15(10):e1008355.
PMID: 31584931
Deficiency in several of the classical human RAD51 paralogs [RAD51B, RAD51C, RAD51D, XRCC2 and XRCC3] is associated with cancer predisposition and Fanconi anemia. To investigate their functions, isogenic disruption mutants...
3.
Baldock R, Pressimone C, Baird J, Khodakov A, Luong T, Grundy M, et al.
DNA Repair (Amst)
. 2019 Mar;
76:99-107.
PMID: 30836272
The proficiency of cancer cells to repair DNA double-strand breaks (DSBs) by homologous recombination (HR) is a key determinant in predicting response to targeted therapies such as PARP inhibitors. The...
4.
Gon S, Loosveld M, Crouzet T, Potier D, Bonnet M, Morin S, et al.
Haematologica
. 2018 Mar;
103(6):999-1007.
PMID: 29567770
Signaling through the αβT cell receptor (TCR) is a crucial determinant of T-cell fate and can induce two opposite outcomes during thymocyte development: cell death or survival and differentiation. To...
5.
Cieslak A, Le Noir S, Trinquand A, Lhermitte L, Franchini D, Villarese P, et al.
J Exp Med
. 2014 Aug;
211(9):1821-32.
PMID: 25135298
V(D)J recombination of TCR loci is regulated by chromatin accessibility to RAG1/2 proteins, rendering RAG1/2 targeting a potentially important regulator of lymphoid differentiation. We show that within the human TCR-α/δ...
6.
Loosveld M, Castellano R, Gon S, Goubard A, Crouzet T, Pouyet L, et al.
Oncotarget
. 2014 Jun;
5(10):3168-72.
PMID: 24930440
T-ALL patients treated with intensive chemotherapy achieve high rates of remission. However, frequent long-term toxicities and relapses into chemotherapy-refractory tumors constitute major clinical challenges which could be met by targeted...
7.
Loosveld M, Bonnet M, Gon S, Montpellier B, Quilichini B, Navarro J, et al.
Genes Chromosomes Cancer
. 2013 Nov;
53(1):52-66.
PMID: 24249258
MYC is a potent oncogene involved in ∼70% of human cancers, inducing tumorigenesis with high penetrance and short latency in experimental transgenic models. Accordingly, MYC is recognized as a major...
8.
Gon S, Napolitano R, Rocha W, Coulon S, Fuchs R
Proc Natl Acad Sci U S A
. 2011 Nov;
108(48):19311-6.
PMID: 22084087
Exposure of Escherichia coli to UV light increases expression of NrdAB, the major ribonucleotide reductase leading to a moderate increase in dNTP levels. The role of elevated dNTP levels during...
9.
Feeney M, Veeravalli K, Boyd D, Gon S, Faulkner M, Georgiou G, et al.
Proc Natl Acad Sci U S A
. 2011 Apr;
108(19):7991-6.
PMID: 21521794
In bacteria, cysteines of cytoplasmic proteins, including the essential enzyme ribonucleotide reductase (RNR), are maintained in the reduced state by the thioredoxin and glutathione/glutaredoxin pathways. An Escherichia coli mutant lacking...
10.
Faulkner M, Veeravalli K, Gon S, Georgiou G, Beckwith J
Proc Natl Acad Sci U S A
. 2008 May;
105(18):6735-40.
PMID: 18456836
In Escherichia coli, the glutathione/glutaredoxin and thioredoxin pathways are essential for the reduction of cytoplasmic protein disulfide bonds, including those formed in the essential enzyme ribonucleotide reductase during its action...