Stephanie Gachet
Overview
Explore the profile of Stephanie Gachet including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
14
Citations
340
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0
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Recent Articles
1.
Sebert M, Gachet S, Leblanc T, Rousseau A, Bluteau O, Kim R, et al.
Cell Stem Cell
. 2023 Feb;
30(2):153-170.e9.
PMID: 36736290
Fanconi anemia (FA) patients experience chromosome instability, yielding hematopoietic stem/progenitor cell (HSPC) exhaustion and predisposition to poor-prognosis myeloid leukemia. Based on a longitudinal cohort of 335 patients, we performed clinical,...
2.
Kim R, Bergugnat H, Larcher L, Duchmann M, Passet M, Gachet S, et al.
Blood Cancer Discov
. 2023 Jan;
4(2):134-149.
PMID: 36630200
Significance: We show that low-hypodiploid ALL is a frequent entity within B-ALL in older adults, relying on somatic TP53 biallelic alteration. Our study unveils a link between aging and low-hypodiploid...
3.
Passet M, Kim R, Gachet S, Sigaux F, Chaumeil J, Galland A, et al.
Blood
. 2022 Mar;
139(24):3505-3518.
PMID: 35316324
Oncogenic alterations underlying B-cell acute lymphoblastic leukemia (B-ALL) in adults remain incompletely elucidated. To uncover novel oncogenic drivers, we performed RNA sequencing and whole-genome analyses in a large cohort of...
4.
Wu H, Rerolle D, Berthier C, Hleihel R, Sakamoto T, Quentin S, et al.
Cancer Discov
. 2021 Jul;
11(12):3198-3213.
PMID: 34301789
Significance: ActD induces complete remissions in NPM1-mutant AMLs. We found that NPM1c affects mitochondrial biogenesis and PML NBs. ActD targets mitochondria, yielding ROS which enforce PML NB biogenesis and restore...
5.
Catherinet C, Passaro D, Gachet S, Medyouf H, Reynaud A, Lasgi C, et al.
PLoS One
. 2021 Jul;
16(7):e0254184.
PMID: 34234374
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy with few available targeted therapies. We previously reported that the phosphatase calcineurin (Cn) is required for LIC (leukemia Initiating Capacity) potential...
6.
Tottone L, Lancho O, Loh J, Singh A, Kimura S, Roels J, et al.
Blood Cancer Discov
. 2021 Jan;
2(1):92-109.
PMID: 33458694
Long-range oncogenic enhancers play an important role in cancer. Yet, whether similar regulation of tumor suppressor genes is relevant remains unclear. Loss of expression of PTEN is associated with the...
7.
Buratin A, Paganin M, Gaffo E, Molin A, Roels J, Germano G, et al.
Blood Adv
. 2020 Dec;
4(23):5902-5914.
PMID: 33259601
Circular RNAs (circRNAs) are stable RNA molecules that can drive cancer through interactions with microRNAs and proteins and by the expression of circRNA encoded peptides. The aim of the study...
8.
Masse A, Roulin L, Pasanisi J, Penneroux J, Gachet S, Delord M, et al.
Leuk Res
. 2019 Nov;
87:106269.
PMID: 31751766
Bromodomain and Extra-Terminal inhibitors (BETi) such as OTX015 are active in Acute Myeloid Leukaemias (AML). Their activity on Leukemic Stem Cells (LSCs) is less documented. We interrogated the anti-LSC activity...
9.
Gachet S, El-Chaar T, Avran D, Genesca E, Catez F, Quentin S, et al.
Cancer Discov
. 2018 Sep;
8(12):1614-1631.
PMID: 30266814
Deletion of chromosome 6q is a well-recognized abnormality found in poor-prognosis T-cell acute lymphoblastic leukemia (T-ALL). Using integrated genomic approaches, we identified two candidate haploinsufficient genes contiguous at 6q14, (encoding...
10.
Bluteau D, Masliah-Planchon J, Clairmont C, Rousseau A, Ceccaldi R, Dubois dEnghien C, et al.
J Clin Invest
. 2017 Mar;
127(3):1117.
PMID: 28248207
No abstract available.