Stephane Zaffran
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Explore the profile of Stephane Zaffran including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
De Bono C, Xu Y, Kausar S, Herbane M, Humbert C, Rafatov S, et al.
Development
. 2025 Feb;
152(5).
PMID: 39927812
Forty first-trimester human hearts were studied to lay groundwork for further studies of the mechanisms underlying congenital heart defects. We first sampled 49,227 cardiac nuclei from three fetuses at 8.6,...
2.
De Bono C, Lescroart F, Zaffran S
Methods Mol Biol
. 2025 Jan;
2889:121-137.
PMID: 39745609
Anterior Hox genes are required for genetic identity and anterior posterior patterning of the second heart field (SHF), which contributes to the formation of the embryonic heart in vertebrates. Defective...
3.
Argiro L, Chevalier C, Choquet C, Nandkishore N, Ghata A, Baudot A, et al.
Nat Commun
. 2024 Nov;
15(1):10172.
PMID: 39580459
Cardiopharyngeal mesoderm contributes to the formation of the heart and head muscles. However, the mechanisms governing cardiopharyngeal mesoderm specification remain unclear. Here, we reproduce cardiopharyngeal mesoderm specification towards cardiac and...
4.
Henderson D, Alqahtani A, Chaudhry B, Cook A, Eley L, Houyel L, et al.
Dis Model Mech
. 2024 Nov;
17(11).
PMID: 39575509
Congenital heart defects (CHDs), the most common congenital anomalies, are considered to have a significant genetic component. However, despite considerable efforts to identify pathogenic genes in patients with CHDs, few...
5.
Jaouadi H, Morel V, Martel H, Lindenbaum P, de la Chapelle L, Herbane M, et al.
Front Med (Lausanne)
. 2024 Nov;
11:1480947.
PMID: 39554508
Background: Approximately half of hypertrophic cardiomyopathy (HCM) patients lack a precise genetic diagnosis. The likelihood of identifying clinically relevant variants increased over time. Methods: In this study, we conducted a...
6.
Retinoic acid signalling regulates branchiomeric neck muscle development at the head/trunk interface
Dumas C, Rousset C, De Bono C, Cortes C, Jullian E, Lescroart F, et al.
Development
. 2024 Jul;
151(16).
PMID: 39082789
Skeletal muscles of the head and trunk originate in distinct lineages with divergent regulatory programmes converging on activation of myogenic determination factors. Branchiomeric head and neck muscles share a common...
7.
Kraoua L, Louati A, Ben Ahmed S, Abida N, Khemiri M, Menif K, et al.
Mol Genet Genomic Med
. 2024 Jun;
12(6):e2486.
PMID: 38924380
Background: Dilated cardiomyopathy (DCM) is characterized by dilatation of the left ventricle, systolic dysfunction, and normal or reduced thickness of the left ventricular wall. It is a leading cause of...
8.
Avierinos J, Tribouilloy C, Bursi F, Grigioni F, Vanoverschelde J, Resseguier N, et al.
Eur Heart J
. 2024 May;
45(26):2306-2316.
PMID: 38751052
Background And Aims: Presentation, outcome, and management of females with degenerative mitral regurgitation (DMR) are undefined. We analysed sex-specific baseline clinical and echocardiographic characteristics at referral for DMR due to...
9.
Ribeiro da Silva A, Gunawan F, Boezio G, Faure E, Theron A, Avierinos J, et al.
Sci Adv
. 2024 May;
10(20):eadl0633.
PMID: 38748804
Biomechanical forces, and their molecular transducers, including key mechanosensitive transcription factor genes, such as , are required for cardiac valve morphogenesis. However, mutants fail to completely recapitulate the valveless phenotype...
10.
Bernheim S, Borgel A, Le Garrec J, Perthame E, Desgrange A, Michel C, et al.
Dev Cell
. 2023 Oct;
58(21):2217-2234.e8.
PMID: 37852253
Despite their burden, most congenital defects remain poorly understood, due to lack of knowledge of embryological mechanisms. Here, we identify Greb1l mutants as a mouse model of crisscross heart. Based...