Stephane Demine
Overview
Explore the profile of Stephane Demine including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
447
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Recent Articles
1.
Gilglioni E, Li A, St-Pierre-Wijckmans W, Shen T, Perez-Chavez I, Hovhannisyan G, et al.
Nat Commun
. 2024 Nov;
15(1):9522.
PMID: 39496584
Fat accumulation, de novo lipogenesis, and glycolysis are key drivers of hepatocyte reprogramming and the consequent metabolic dysfunction-associated steatotic liver disease (MASLD). Here we report that obesity leads to dysregulated...
2.
Syed F, Ballew O, Lee C, Rana J, Krishnan P, Castela A, et al.
bioRxiv
. 2024 May;
PMID: 38766166
Tyrosine protein-kinase 2 (TYK2), a member of the Janus kinase family, mediates inflammatory signaling through multiple cytokines, including interferon-α (IFNα), interleukin (IL)-12, and IL-23. Missense mutations in TYK2 are associated...
3.
Vandenbempt V, Eski S, Brahma M, Li A, Negueruela J, Bruggeman Y, et al.
iScience
. 2024 Jan;
27(1):108694.
PMID: 38213620
An altered gut microbiota is associated with type 1 diabetes (T1D), affecting the production of short-chain fatty acids (SCFA) and glucose homeostasis. We previously demonstrated that enhancing serum acetate and...
4.
Brahma M, Xiao P, Popa M, Negueruela J, Vandenbempt V, Demine S, et al.
Nutrients
. 2022 Sep;
14(18).
PMID: 36145242
The loss of functional pancreatic β-cell mass is an important hallmark of both type 1 and type 2 diabetes. The RNA-binding protein NOVA1 is expressed in human and rodent pancreatic...
5.
Szymczak F, Alvelos M, Marin-Canas S, Castela A, Demine S, Colli M, et al.
Sci Adv
. 2022 Sep;
8(37):eabn5732.
PMID: 36103539
IFNα is a key regulator of the dialogue between pancreatic β cells and the immune system in early type 1 diabetes (T1D). IFNα up-regulates HLA class I expression in human...
6.
Demine S, Schulte M, Territo P, Eizirik D
Int J Mol Sci
. 2020 Oct;
21(19).
PMID: 33019671
There are presently no reliable ways to quantify human pancreatic beta cell mass (BCM) in vivo, which prevents an accurate understanding of the progressive beta cell loss in diabetes or...
7.
Demine S, Schiavo A, Marin-Canas S, Marchetti P, Cnop M, Eizirik D
Stem Cell Res Ther
. 2020 Jan;
11(1):7.
PMID: 31900242
Background: Adult human pancreatic beta cells are the "gold standard" for studies on diabetes pathogenesis, but their use is limited by insufficient availability and variable quality. An important effort has...
8.
Demine S, Garcia Ribeiro R, Thevenet J, Marselli L, Marchetti P, Pattou F, et al.
Diabetologia
. 2019 Dec;
63(4):825-836.
PMID: 31873789
Aims/hypothesis: Type 1 diabetes is characterised by a progressive decline in beta cell mass. This is also observed following implantation of pancreatic islet allografts, but there is no reliable information...
9.
Demine S, Renard P, Arnould T
Cells
. 2019 Aug;
8(8).
PMID: 31366145
Mitochondrial uncoupling can be defined as a dissociation between mitochondrial membrane potential generation and its use for mitochondria-dependent ATP synthesis. Although this process was originally considered a mitochondrial dysfunction, the...
10.
Cosentino C, Toivonen S, Diaz Villamil E, Atta M, Ravanat J, Demine S, et al.
Nucleic Acids Res
. 2018 Sep;
46(19):10302-10318.
PMID: 30247717
Transfer RNAs (tRNAs) are non-coding RNA molecules essential for protein synthesis. Post-transcriptionally they are heavily modified to improve their function, folding and stability. Intronic polymorphisms in CDKAL1, a tRNA methylthiotransferase,...