Stephane Becart
Overview
Explore the profile of Stephane Becart including associated specialties, affiliations and a list of published articles.
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23
Citations
386
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0
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Recent Articles
1.
Larange A, Takazawa I, Kakugawa K, Thiault N, Ngoi S, Olive M, et al.
Immunity
. 2023 Aug;
56(9):2054-2069.e10.
PMID: 37597518
Ligation of retinoic acid receptor alpha (RARα) by RA promotes varied transcriptional programs associated with immune activation and tolerance, but genetic deletion approaches suggest the impact of RARα on TCR...
2.
Moon J, Younis S, Ramadoss N, Iyer R, Sheth K, Sharpe O, et al.
Nat Commun
. 2023 Jan;
14(1):319.
PMID: 36658110
The immune mechanisms that mediate synovitis and joint destruction in rheumatoid arthritis (RA) remain poorly defined. Although increased levels of CD8 T cells have been described in RA, their function...
3.
Sonigra A, Nel H, Wehr P, Ramnoruth N, Patel S, van Schie K, et al.
JCI Insight
. 2022 Oct;
7(20).
PMID: 36278483
BACKGROUNDAntigen-specific regulation of autoimmune disease is a major goal. In seropositive rheumatoid arthritis (RA), T cell help to autoreactive B cells matures the citrullinated (Cit) antigen-specific immune response, generating RA-specific...
4.
Becart S, Whittington K, Prislovsky A, Rao N, Rosloniec E
PLoS One
. 2021 Jan;
16(1):e0245541.
PMID: 33465118
While antibodies to citrullinated proteins have become a diagnostic hallmark in rheumatoid arthritis (RA), we still do not understand how the autoimmune T cell response is influenced by these citrullinated...
5.
Damm-Ganamet K, Arora N, Becart S, Edwards J, Lebsack A, McAllister H, et al.
J Chem Inf Model
. 2019 Mar;
59(5):2046-2062.
PMID: 30817167
At the onset of a drug discovery program, the goal is to identify novel compounds with appropriate chemical features that can be taken forward as lead series. Here, we describe...
6.
Sidney J, Becart S, Zhou M, Duffy K, Lindvall M, Moore E, et al.
PLoS One
. 2017 May;
12(5):e0177140.
PMID: 28481943
It has been hypothesized that HLA class II alleles associated with rheumatoid arthritis (RA) preferentially present self-antigens altered by post-translational modification, such as citrullination. To understand the role of citrullination...
7.
Cote M, Fos C, Canonigo-Balancio A, Ley K, Becart S, Altman A
J Cell Sci
. 2015 Oct;
128(23):4341-52.
PMID: 26483383
SLAT (also known as DEF6) promotes T cell activation and differentiation by regulating NFAT-Ca(2+) signaling. However, its role in TCR-mediated inside-out signaling, which induces integrin activation and T cell adhesion,...
8.
Fos C, Becart S, Canonigo Balancio A, Boehning D, Altman A
Sci Signal
. 2014 Oct;
7(345):ra93.
PMID: 25270259
The guanine nucleotide exchange factor SLAT (SWAP-70-like adaptor of T cells) regulates T cell activation and differentiation by enabling Ca(2+) release from intracellular stores in response to stimulation of the...
9.
Kumari J, Selvan S, Becart S, Chattopadhyay S, Dalmo R
J Immunol Res
. 2014 Apr;
2014:632632.
PMID: 24741611
No abstract available.
10.
Kong K, Fu G, Zhang Y, Yokosuka T, Casas J, Canonigo-Balancio A, et al.
Nat Immunol
. 2014 Apr;
15(5):465-72.
PMID: 24705298
Regulatory T (Treg) cells, which maintain immune homeostasis and self-tolerance, form an immunological synapse (IS) with antigen-presenting cells (APCs). However, signaling events at the Treg cell IS remain unknown. Here...