Stephan Reiling
Overview
Explore the profile of Stephan Reiling including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
295
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Recent Articles
1.
Vaz R, Li Y, Chellaraj V, Reiling S, Kuntzweiler T, Yang D, et al.
Bioorg Med Chem Lett
. 2018 Aug;
28(19):3194-3196.
PMID: 30146095
This work describes the rational amelioration of Cytochrome P450 4/5 (CYP3A4/5) induction through the Pregnane-X Receptor (PXR) pathway in a series of compounds that modulate the metabotropic glutamate Receptor 2...
2.
Koundinya M, Sudhalter J, Courjaud A, Lionne B, Touyer G, Bonnet L, et al.
Cell Chem Biol
. 2018 Apr;
25(6):705-717.e11.
PMID: 29628435
Activating KRAS mutations are major oncogenic drivers in multiple tumor types. Synthetic lethal screens have previously been used to identify targets critical for the survival of KRAS mutant cells, but...
3.
Guo H, Camargo L, Yeboah F, Digan M, Niu H, Pan Y, et al.
Sci Rep
. 2017 Sep;
7(1):11608.
PMID: 28912557
N-methyl-D-aspartate-receptors (NMDARs) are ionotropic glutamate receptors that function in synaptic transmission, plasticity and cognition. Malfunction of NMDARs has been implicated in a variety of nervous system disorders, making them attractive...
4.
Dinkla K, Strobelt H, Genest B, Reiling S, Borowsky M, Pfister H
IEEE Trans Vis Comput Graph
. 2016 Nov;
23(1):591-600.
PMID: 27875174
High-throughput and high-content screening enables large scale, cost-effective experiments in which cell cultures are exposed to a wide spectrum of drugs. The resulting multivariate data sets have a large but...
5.
Jogalekar A, Reiling S, Vaz R
Bioorg Med Chem Lett
. 2010 Sep;
20(22):6616-9.
PMID: 20875740
The aryl hydrocarbon receptor (AHR) is one of the principal xenobiotic receptors in living organisms and is responsible for interacting with several drugs and environmental toxins, most notably tetrachlorodibenzodioxin (TCDD)....
6.
Vaz R, Zamora I, Li Y, Reiling S, Shen J, Cruciani G
Expert Opin Drug Metab Toxicol
. 2010 Jun;
6(7):851-61.
PMID: 20565339
Importance Of The Field: The site of metabolism (SOM) predictions by CYP 3A4 are extremely important during the drug discovery process especially during the lead discovery or library design phases....
7.
Shen J, Zhu C, Reiling S, Vaz R
Spectrochim Acta A Mol Biomol Spectrosc
. 2010 May;
76(3-4):418-22.
PMID: 20451442
A novel method, SimIR/VCD, for comparing experimental and calculated VCD (vibrational circular dichroism) spectra is developed, based on newly defined spectra similarities. With computationally optimized frequency scaling and shifting, a...
8.
Li Y, Angelastro M, Shimshock S, Reiling S, Vaz R
Bioorg Med Chem Lett
. 2009 Nov;
20(1):338-40.
PMID: 19914067
The reaction pathways of deprotonation versus nucleophilic substitution involving mPGES-2 enzyme catalysis were investigated by ab initio molecular orbital theory calculations for the reaction of methylthiolate with the endoperoxide core...
9.
McLean L, Zhang Y, Li H, Li Z, Lukasczyk U, Choi Y, et al.
Bioorg Med Chem Lett
. 2009 Oct;
19(23):6717-20.
PMID: 19836948
Biochemical and X-ray crystallographic studies confirmed that hydroxyquinoline derivatives identified by virtual screening were actually covalent inhibitors of the MIF tautomerase. Adducts were formed by N-alkylation of the Pro-1 at...
10.
Li Y, Zhu F, Vaidehi N, Goddard 3rd W, Sheinerman F, Reiling S, et al.
J Am Chem Soc
. 2007 Aug;
129(35):10720-31.
PMID: 17691773
Prostanoids play important physiological roles in the cardiovascular and immune systems and in pain sensation in peripheral systems through their interactions with eight G-protein coupled receptors. These receptors are important...