Robert C Glen
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Explore the profile of Robert C Glen including associated specialties, affiliations and a list of published articles.
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95
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2468
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Recent Articles
1.
Shah S, Knausenberger T, Pontifex M, Connell E, Le Gall G, Hardy T, et al.
Gut Microbes
. 2024 Nov;
16(1):2431651.
PMID: 39582109
The gut microbiota-brain axis has been associated with the pathogenesis of numerous disorders, but the mechanism(s) underlying these links are generally poorly understood. Accumulating evidence indicates the involvement of gut...
2.
Williams T, Nyimanu D, Kuc R, Foster R, Glen R, Maguire J, et al.
Front Pharmacol
. 2024 Apr;
15:1369489.
PMID: 38655187
Pulmonary arterial hypertension (PAH) is characterised by endothelial dysfunction and pathological vascular remodelling, resulting in the occlusion of pulmonary arteries and arterioles, right ventricular hypertrophy, and eventually fatal heart failure....
3.
Boby M, Fearon D, Ferla M, Filep M, Koekemoer L, Robinson M, et al.
Science
. 2023 Nov;
382(6671):eabo7201.
PMID: 37943932
We report the results of the COVID Moonshot, a fully open-science, crowdsourced, and structure-enabled drug discovery campaign targeting the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease. We discovered...
4.
Hoyles L, Pontifex M, Rodriguez-Ramiro I, Anis-Alavi M, Jelane K, Snelling T, et al.
Microbiome
. 2021 Nov;
9(1):235.
PMID: 34836554
Background: Communication between the gut microbiota and the brain is primarily mediated via soluble microbe-derived metabolites, but the details of this pathway remain poorly defined. Methylamines produced by microbial metabolism...
5.
Ingwersen T, Linnenberg C, DAcunto E, Temori S, Paolucci I, Wasilewski D, et al.
Sci Rep
. 2021 Apr;
11(1):8766.
PMID: 33888787
Familial encephalopathy with neuroserpin inclusion bodies (FENIB) is a progressive neurodegenerative disease caused by point mutations in the gene for neuroserpin, a serine protease inhibitor of the nervous system. Different...
6.
Read C, Nyimanu D, Yang P, Kuc R, Williams T, Fitzpatrick C, et al.
Front Pharmacol
. 2021 Mar;
11:588669.
PMID: 33716722
Signaling through the apelin receptor is beneficial for a number of diseases including pulmonary arterial hypertension. The endogenous small peptides, apelin and elabela/toddler, are downregulated in pulmonary arterial hypertension but...
7.
Iacovacci J, Peluso A, Ebbels T, Ralser M, Glen R
Metabolites
. 2020 Nov;
10(11).
PMID: 33137869
Mass spectrometry technologies are widely used in the fields of ionomics and metabolomics to simultaneously profile the intracellular concentrations of, e.g., amino acids or elements in genome-wide mutant libraries. These...
8.
Liu K, Acharjee A, Hinz C, Liggi S, Murgia A, Denes J, et al.
J Proteome Res
. 2020 Jul;
19(10):3919-3935.
PMID: 32646215
Obesity is a complex disorder where the genome interacts with diet and environmental factors to ultimately influence body mass, composition, and shape. Numerous studies have investigated how bulk lipid metabolism...
9.
Koundouros N, Karali E, Tripp A, Valle A, Inglese P, Perry N, et al.
Cell
. 2020 Jun;
181(7):1596-1611.e27.
PMID: 32559461
Oncogenic transformation is associated with profound changes in cellular metabolism, but whether tracking these can improve disease stratification or influence therapy decision-making is largely unknown. Using the iKnife to sample...
10.
Bender A, Jenkins J, Li Q, Adams S, Cannon E, Glen R
Annu Rep Comput Chem
. 2020 May;
2:141-168.
PMID: 32362803
This chapter discusses recent developments in some of the areas that exploit the molecular similarity principle, novel approaches to capture molecular properties by the use of novel descriptors, focuses on...