Stephan P Tenbaum
Overview
Explore the profile of Stephan P Tenbaum including associated specialties, affiliations and a list of published articles.
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12
Citations
612
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Recent Articles
1.
Puig I, Tenbaum S, Chicote I, Arques O, Martinez-Quintanilla J, Cuesta-Borras E, et al.
J Clin Invest
. 2018 Jun;
128(9):3887-3905.
PMID: 29944140
Dormant or slow-cycling tumor cells can form a residual chemoresistant reservoir responsible for relapse in patients, years after curative surgery and adjuvant therapy. We have adapted the pulse-chase expression of...
2.
Herrero A, Pinto A, Colon-Bolea P, Casar B, Jones M, Agudo-Ibanez L, et al.
Cancer Cell
. 2015 Aug;
28(2):170-82.
PMID: 26267534
Nearly 50% of human malignancies exhibit unregulated RAS-ERK signaling; inhibiting it is a valid strategy for antineoplastic intervention. Upon activation, ERK dimerize, which is essential for ERK extranuclear, but not...
3.
Arques O, Chicote I, Puig I, Tenbaum S, Argiles G, Dienstmann R, et al.
Clin Cancer Res
. 2015 Jul;
22(3):644-56.
PMID: 26224873
Purpose: Oncogenic mutations in the KRAS/PI3K/AKT pathway are one of the most frequent alterations in cancer. Although PI3K or AKT inhibitors show promising results in clinical trials, drug resistance frequently...
4.
Puig I, Chicote I, Tenbaum S, Arques O, Herance J, Gispert J, et al.
Clin Cancer Res
. 2013 Oct;
19(24):6787-801.
PMID: 24170545
Purpose: Within the aim of advancing precision oncology, we have generated a collection of patient-derived xenografts (PDX) characterized at the molecular level, and a preclinical model of colon cancer metastasis...
5.
Tenbaum S, Ordonez-Moran P, Puig I, Chicote I, Arques O, Landolfi S, et al.
Nat Med
. 2012 May;
18(6):892-901.
PMID: 22610277
The Wnt–β-catenin and PI3K-AKT-FOXO3a pathways have a central role in cancer. AKT phosporylates FOXO3a, relocating it from the cell nucleus to the cytoplasm, an effect that is reversed by PI3K...
6.
Martinez-Iglesias O, Garcia-Silva S, Tenbaum S, Regadera J, Larcher F, Paramio J, et al.
Cancer Res
. 2009 Jan;
69(2):501-9.
PMID: 19147563
Loss of thyroid hormone receptors (TR) is a common feature in some tumors, although their role in tumor progression is currently unknown. We show here that expression of TRbeta1 in...
7.
Tenbaum S, Papaioannou M, Reeb C, Goeman F, Escher N, Kob R, et al.
Biochim Biophys Acta
. 2007 Jun;
1773(9):1447-54.
PMID: 17570542
Recently, using a proteomic approach we have identified the corepressor Alien as a novel interacting factor of the cell cycle regulator E2F1. Unclear was whether this interaction influences cell proliferation...
8.
Nevado J, Tenbaum S, Castillo A, Sanchez-Pacheco A, Aranda A
J Mol Endocrinol
. 2007 Jun;
38(6):587-601.
PMID: 17556530
The genetic predisposition of the host and the virus is the most important determinant for prediction of the course of human immunodeficiency virus type I (HIV-1) viral infection and acquired...
9.
Escher N, Kob R, Tenbaum S, Eisold M, Baniahmad A, von Eggeling F, et al.
J Proteome Res
. 2007 Mar;
6(3):1158-64.
PMID: 17330949
Proteins perform their activities in cells by the cooperation within protein complexes. For this reason, it is important to investigate protein-protein interactions to receive insights in physiological processes. A multitude...
10.
hSrb7, an essential human Mediator component, acts as a coactivator for the thyroid hormone receptor
Nevado J, Tenbaum S, Aranda A
Mol Cell Endocrinol
. 2004 Jul;
222(1-2):41-51.
PMID: 15249124
Nuclear hormone receptors interact with the basal-transcriptional complex and/or coactivators to regulate transcriptional activation. These activator-target interactions recruit the transcriptional machinery to the promoter and may also stimulate transcriptional events...