Presynaptic Regulators in Memory Formation

Overview

Journal Learn Mem

Specialty Neurology

Date 2024 Jun 11

PMID 38862173

Authors

Oriane Turrel

Lili Gao

Stephan J Sigrist

Affiliations

Soon will be listed here.

Abstract

The intricate molecular and structural sequences guiding the formation and consolidation of memories within neuronal circuits remain largely elusive. In this study, we investigate the roles of two pivotal presynaptic regulators, the small GTPase Rab3, enriched at synaptic vesicles, and the cell adhesion protein Neurexin-1, in the formation of distinct memory phases within the mushroom body Kenyon cells. Our findings suggest that both proteins play crucial roles in memory-supporting processes within the presynaptic terminal, operating within distinct plasticity modules. These modules likely encompass remodeling and maturation of existing active zones (AZs), as well as the formation of new AZs.

Citing Articles

What do the mushroom bodies do for the insect brain? Twenty-five years of progress.

Fiala A, Kaun K Learn Mem. 2024; 31(5).

PMID: 38862175 PMC: 11199942. DOI: 10.1101/lm.053827.123.

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