Michael Groll
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Explore the profile of Michael Groll including associated specialties, affiliations and a list of published articles.
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189
Citations
4264
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Recent Articles
1.
Klaubert T, Gellner J, Bernard C, Effert J, Lombard C, Kaila V, et al.
Nat Commun
. 2025 Feb;
16(1):1348.
PMID: 39905070
Azetidine-2-carboxylic acid (AZE) is a long-known plant metabolite. Recently, AZE synthases have been identified in bacterial natural product pathways involving non-ribosomal peptide synthetases. AZE synthases catalyse the intramolecular 4-exo-tet cyclisation...
2.
Su L, Huber E, Westphalen M, Gellner J, Bode E, Kobel T, et al.
Angew Chem Int Ed Engl
. 2024 Aug;
63(49):e202410799.
PMID: 39185606
Dithiolopyrrolone (DTP) natural products are produced by several different bacteria and have potent antibacterial, antifungal and anticancer activities. While the amide of their DTP core can be methylated to fine-tune...
3.
Kuttenlochner W, Beller P, Kaysser L, Groll M
J Biol Chem
. 2024 Aug;
300(9):107646.
PMID: 39121999
Cystargolides and belactosins are natural products with a distinct dipeptide structure and an electrophilic β-lactone warhead. They are known to inhibit proteases such as the proteasome or caseinolytic protease P,...
4.
Gotz M, Godwin K, Price R, Dorn R, Merrill-Steskal G, Klemmer W, et al.
ACS Med Chem Lett
. 2024 Apr;
15(4):533-539.
PMID: 38628795
Peptide macrocycles have recently gained attention as protease inhibitors due to their metabolic stability and specificity. However, the development of peptide macrocycles with improved binding potency has so far been...
5.
Bozhuyuk K, Prave L, Kegler C, Schenk L, Kaiser S, Schelhas C, et al.
Science
. 2024 Mar;
383(6689):eadg4320.
PMID: 38513038
Many clinically used drugs are derived from or inspired by bacterial natural products that often are produced through nonribosomal peptide synthetases (NRPSs), megasynthetases that activate and join individual amino acids...
6.
Schmalhofer M, Vagstad A, Zhou Q, Bode H, Groll M
Adv Sci (Weinh)
. 2024 Mar;
11(22):e2400184.
PMID: 38491909
Pigments such as anthraquinones (AQs) and melanins are antioxidants, protectants, or virulence factors. AQs from the entomopathogenic bacterium Photorhabdus laumondii are produced by a modular type II polyketide synthase system....
7.
Morstein J, Amatuni A, Shuster A, Kuttenlochner W, Ko T, Abegg D, et al.
Angew Chem Int Ed Engl
. 2023 Dec;
63(8):e202314791.
PMID: 38109686
Photolipids have emerged as attractive tools for the optical control of lipid functions. They often contain an azobenzene photoswitch that imparts a cis double-bond upon irradiation. Herein, we present the...
8.
Beller P, Fink P, Wolf F, Mannle D, Helmle I, Kuttenlochner W, et al.
J Biol Chem
. 2023 Nov;
300(1):105507.
PMID: 38029966
Cystargolides are natural products originally isolated from Kitasatospora cystarginea NRRL B16505 as inhibitors of the proteasome. They are composed of a dipeptide backbone linked to a β-lactone warhead. Recently, we...
9.
Illigmann A, Vielberg M, Lakemeyer M, Wolf F, Dema T, Stange P, et al.
Angew Chem Int Ed Engl
. 2023 Nov;
63(3):e202314028.
PMID: 38029352
The caseinolytic protease is a highly conserved serine protease, crucial to prokaryotic and eukaryotic protein homeostasis, and a promising antibacterial and anticancer drug target. Herein, we describe the potent cystargolides...
10.
Huber E, Groll M, Ortlund E
Structure
. 2023 Jul;
31(7):762-763.
PMID: 37419100
In this meet-the-author Q&A, Cell Press Community Review editor Leslie Nitsche speaks to Eric Ortlund as well as Eva Huber and Michael Groll from the Groll group about their recent...