Stefano Espinoza
Overview
Explore the profile of Stefano Espinoza including associated specialties, affiliations and a list of published articles.
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46
Citations
1051
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Recent Articles
11.
Valentini P, Pierattini B, Zacco E, Mangoni D, Espinoza S, Webster N, et al.
Mol Ther Nucleic Acids
. 2022 Mar;
27:1092-1102.
PMID: 35228902
SINEUPs are a novel class of natural and synthetic non-coding antisense RNA molecules able to increase the translation of a target mRNA. They present a modular organization comprising an unstructured...
12.
Arnoldi M, Zarantonello G, Espinoza S, Gustincich S, Di Leva F, Biagioli M
Methods Mol Biol
. 2022 Feb;
2434:63-87.
PMID: 35213010
SINEUP is a new class of long non-coding RNAs (lncRNAs) which contain an inverted Short Interspersed Nuclear Element (SINE) B2 element (invSINEB2) necessary to specifically upregulate target gene translation. Originally...
13.
Espinoza S, Bon C, Valentini P, Pierattini B, Matey A, Damiani D, et al.
Essays Biochem
. 2021 Oct;
65(4):775-789.
PMID: 34623427
RNA molecules have emerged as a new class of promising therapeutics to expand the range of druggable targets in the genome. In addition to 'canonical' protein-coding mRNAs, the emerging richness...
14.
Sanna F, Bratzu J, Serra M, Leo D, Quartu M, Boi M, et al.
Front Behav Neurosci
. 2020 May;
14:58.
PMID: 32372926
Central dopamine plays a key role in sexual behavior. Recently, a Dopamine Transporter knockout (DAT KO) rat has been developed, which displays several behavioral dysfunctions that have been related to...
15.
Espinoza S, Sukhanov I, Efimova E, Kozlova A, Antonova K, Illiano P, et al.
Front Mol Neurosci
. 2020 Mar;
13:18.
PMID: 32194374
Trace amine-associated receptors (TAARs) are a class of G-protein-coupled receptors found in mammals. While TAAR1 is expressed in several brain regions, all the other TAARs have been described mainly in...
16.
Bon C, Luffarelli R, Russo R, Fortuni S, Pierattini B, Santulli C, et al.
Nucleic Acids Res
. 2019 Oct;
47(20):10728-10743.
PMID: 31584077
Friedreich's ataxia (FRDA) is an untreatable disorder with neuro- and cardio-degenerative progression. This monogenic disease is caused by the hyper-expansion of naturally occurring GAA repeats in the first intron of...
17.
Espinoza S, Scarpato M, Damiani D, Manago F, Mereu M, Contestabile A, et al.
Mol Ther
. 2019 Sep;
28(2):642-652.
PMID: 31495777
Glial cell-derived neurotrophic factor (GDNF) has a potent action in promoting the survival of dopamine (DA) neurons. Several studies indicate that increasing GDNF levels may be beneficial for the treatment...
18.
Lam V, Mielnik C, Baimel C, Beerepoot P, Espinoza S, Sukhanov I, et al.
Front Pharmacol
. 2018 Sep;
9:953.
PMID: 30233365
The trace amine associated receptor 1 (TAAR1) is a G-protein coupled receptor expressed in the monoaminergic regions of the brain, and represents a potential novel therapeutic target for the treatment...
19.
Espinoza S, Leo D, Sotnikova T, Shahid M, Kaariainen T, Gainetdinov R
Front Pharmacol
. 2018 Jul;
9:645.
PMID: 29977204
Trace amine-associated receptor 1 (TAAR1) is a G protein-coupled receptor, which signals through elevating intracellular cAMP levels, and expressed in most vertebrates, including rodents and humans. In recent years, several...
20.
Schwartz M, Canales J, Zucchi R, Espinoza S, Sukhanov I, Gainetdinov R
Expert Opin Ther Targets
. 2018 May;
22(6):513-526.
PMID: 29798691
The trace amines, endogenous amines closely related to the biogenic amine neurotransmitters, have been known to exert physiological and neurological effects for decades. The recent identification of a trace amine-sensitive...