Stefan Schoebel
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Explore the profile of Stefan Schoebel including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
436
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Recent Articles
1.
Wang H, Schoebel S, Schmitz F, Dong H, Hedfalk K
MethodsX
. 2020 Mar;
7:100816.
PMID: 32195136
Hydrogen peroxide (HO) is an important signal molecule produced in animal and plant cells. The balance of HO between the intra- and extracellular space is regulated by integral membrane proteins,...
2.
Wang H, Schoebel S, Schmitz F, Dong H, Hedfalk K
Biochim Biophys Acta Biomembr
. 2019 Sep;
1862(2):183065.
PMID: 31521632
Aquaporins are membrane-intrinsic proteins initially defined as water (HO) channels in all organisms and subsequently found to have multiple substrate specificities, such as hydrogen peroxide (HO). HO is a signaling...
3.
Schoebel S, Mi W, Stein A, Ovchinnikov S, Pavlovicz R, DiMaio F, et al.
Nature
. 2017 Jul;
548(7667):352-355.
PMID: 28682307
Misfolded endoplasmic reticulum proteins are retro-translocated through the membrane into the cytosol, where they are poly-ubiquitinated, extracted from the membrane, and degraded by the proteasome-a pathway termed endoplasmic reticulum-associated protein...
4.
Muller M, Shkumatov A, Oesterlin L, Schoebel S, Goody P, Goody R, et al.
J Biol Chem
. 2012 Aug;
287(42):35036-35046.
PMID: 22872634
After the pathogenic bacterium Legionella pneumophila is phagocytosed, it injects more than 250 different proteins into the cytoplasm of host cells to evade lysosomal digestion and to replicate inside the...
5.
Schoebel S, Cichy A, Goody R, Itzen A
Proc Natl Acad Sci U S A
. 2011 Oct;
108(44):17945-50.
PMID: 22011575
The causative agent of Legionnaires disease, Legionella pneumophila, injects several hundred proteins into the cell it infects, many of which interfere with or exploit vesicular transport processes. One of these...
6.
Goody R, Muller M, Schoebel S, Oesterlin L, Blumer J, Peters H, et al.
Commun Integr Biol
. 2011 Apr;
4(1):72-4.
PMID: 21509184
The human pathogen Legionella pneumophila is a bacterium that infects human cells and interferes with intracellular signaling. The Legionella protein DrrA is one of the numerous effectors that the bacterium...
7.
Hou X, Hagemann N, Schoebel S, Blankenfeldt W, Goody R, Erdmann K, et al.
EMBO J
. 2011 Mar;
30(8):1659-70.
PMID: 21378754
The oculocerebrorenal syndrome of Lowe (OCRL), also called Lowe syndrome, is characterized by defects of the nervous system, the eye and the kidney. Lowe syndrome is a monogenetic X-linked disease...
8.
Schoebel S, Blankenfeldt W, Goody R, Itzen A
EMBO Rep
. 2010 Jul;
11(8):598-604.
PMID: 20616805
The DrrA protein of Legionella pneumophila is involved in mistargeting of endoplasmic reticulum-derived vesicles to Legionella-containing vacuoles through recruitment of the small GTPase Rab1. To this effect, DrrA binds specifically...
9.
Schoebel S, Oesterlin L, Blankenfeldt W, Goody R, Itzen A
Mol Cell
. 2010 Jan;
36(6):1060-72.
PMID: 20064470
Prenylated Rab proteins exist in the cytosol as soluble, high-affinity complexes with GDI that need to be disrupted for membrane attachment and targeting of Rab proteins. The Legionella pneumophila protein...
10.
Bergbrede T, Chuky N, Schoebel S, Blankenfeldt W, Geyer M, Fuchs E, et al.
J Biol Chem
. 2008 Nov;
284(5):2628-2635.
PMID: 19019823
Rab GTPases are key regulators of intracellular vesicular transport that control vesicle budding, cargo sorting, transport, tethering, and fusion. In the inactive (GDP-bound) conformation, Rab GTPases are targeted to intracellular...