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Stefan Schattgen

Explore the profile of Stefan Schattgen including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 187
Followers 0
Related Specialties
Biology
Cell Biology
Molecular Biology
Top 10 Co-Authors
Paul G Thomas
Andrew Fiore-Gartland
Katherine Fitzgerald
Aisha Souquette
Jessica A Gaevert
Tomer Hertz
Liel Cohen-Lavi
Koshlan Mayer-Blackwell
Philip Bradley
Wei Wang
Published In
J Virol
bioRxiv
Res Sq
Cell Rep
Elife
Affiliations
Soon will be listed here.
Recent Articles
1.
Antigen-specific CD4 T cells exhibit distinct transcriptional phenotypes in the lymph node and blood following vaccination in humans
Mudd P, Borcherding N, Kim W, Quinn M, Han F, Zhou J, et al.
Res Sq . 2023 Oct; PMID: 37790414
SARS-CoV-2 infection and mRNA vaccination induce robust CD4 T cell responses that are critical for the development of protective immunity. Here, we evaluated spike-specific CD4 T cells in the blood...
2.
PTEN directs developmental and metabolic signaling for innate-like T cell fate and tissue homeostasis
Blanco D, Chapman N, Raynor J, Xu C, Su W, Kc A, et al.
Nat Cell Biol . 2022 Oct; 24(11):1642-1654. PMID: 36302969
Phosphatase and tensin homologue (PTEN) is frequently mutated in human cancer, but its roles in lymphopoiesis and tissue homeostasis remain poorly defined. Here we show that PTEN orchestrates a two-step...
3.
TCR meta-clonotypes for biomarker discovery with enabled identification of public, HLA-restricted clusters of SARS-CoV-2 TCRs
Mayer-Blackwell K, Schattgen S, Cohen-Lavi L, Crawford J, Souquette A, Gaevert J, et al.
Elife . 2021 Nov; 10. PMID: 34845983
T-cell receptors (TCRs) encode clinically valuable information that reflects prior antigen exposure and potential future response. However, despite advances in deep repertoire sequencing, enormous TCR diversity complicates the use of...
4.
TCR meta-clonotypes for biomarker discovery with tcrdist3: identification of public, HLA-restricted SARS-CoV-2 associated TCR features
Mayer-Blackwell K, Schattgen S, Cohen-Lavi L, Crawford J, Souquette A, Gaevert J, et al.
bioRxiv . 2021 Jan; PMID: 33398288
As the mechanistic basis of adaptive cellular antigen recognition, T cell receptors (TCRs) encode clinically valuable information that reflects prior antigen exposure and potential future response. However, despite advances in...
5.
Immature lung TNFR2 conventional DC 2 subpopulation activates moDCs to promote cyclic di-GMP mucosal adjuvant responses in vivo
Mansouri S, Patel S, Katikaneni D, Blaauboer S, Wang W, Schattgen S, et al.
Mucosal Immunol . 2018 Oct; 12(1):277-289. PMID: 30327534
Cyclic dinucleotides (CDNs), including cyclic di-GMP (CDG), are promising vaccine adjuvants in preclinical/clinical trials. The in vivo mechanisms of CDNs are not clear. Here we investigated the roles of lung...
6.
A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In Vivo Infection
Tzeng T, Schattgen S, Monks B, Wang D, Cerny A, Latz E, et al.
Cell Rep . 2016 Jun; 16(2):571-582. PMID: 27346360
Inflammasome activation is associated with numerous diseases. However, in vivo detection of the activated inflammasome complex has been limited by a dearth of tools. We have developed transgenic mice that...
7.
RNA helicase signaling is critical for type i interferon production and protection against Rift Valley fever virus during mucosal challenge
Ermler M, Yerukhim E, Schriewer J, Schattgen S, Traylor Z, Wespiser A, et al.
J Virol . 2013 Feb; 87(9):4846-60. PMID: 23408632
Rift Valley fever virus (RVFV) is an emerging RNA virus with devastating economic and social consequences. Clinically, RVFV induces a gamut of symptoms ranging from febrile illness to retinitis, hepatic...