Philip Bradley
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Explore the profile of Philip Bradley including associated specialties, affiliations and a list of published articles.
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66
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5422
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Recent Articles
1.
Elyaman W, Stern L, Jiang N, Dressman D, Bradley P, Klatzmann D, et al.
Alzheimers Dement
. 2025 Jan;
21(2):e14548.
PMID: 39868844
This proceedings article summarizes the inaugural "T Cells in the Brain" symposium held at Columbia University. Experts gathered to explore the role of T cells in neurodegenerative diseases. Key topics...
2.
Russell M, Trofimov A, Bradley P, Matsen 4th F
bioRxiv
. 2024 Oct;
PMID: 39464162
V(D)J recombination generates the diverse B and T cell receptors essential for recognizing a wide array of antigens. This diversity arises from the combinatorial assembly of V(D)J genes and the...
3.
Lee J, Chen E, Hu T, Perret R, Chaffee M, Martinov T, et al.
bioRxiv
. 2024 Sep;
PMID: 39345486
One-sentence Summary: Tumor cell methylation of KRAS epitope in HLA-A2 permits immune evasion, and new TCRs were generated to overcome this with engineered cell therapy.
4.
Cross D, Layton E, Yu K, Smith M, Aguilar M, Li S, et al.
JCI Insight
. 2024 May;
9(9).
PMID: 38716731
T cells are required for protective immunity against Mycobacterium tuberculosis. We recently described a cohort of Ugandan household contacts of tuberculosis cases who appear to "resist" M. tuberculosis infection (resisters;...
5.
Pun M, Ivanov A, Bellamy Q, Montague Z, LaMont C, Bradley P, et al.
Proc Natl Acad Sci U S A
. 2024 Feb;
121(6):e2300838121.
PMID: 38300863
Proteins play a central role in biology from immune recognition to brain activity. While major advances in machine learning have improved our ability to predict protein structure from sequence, determining...
6.
Liu S, Bradley P, Sun W
PLoS Comput Biol
. 2023 Nov;
19(11):e1011664.
PMID: 37983288
T cells rely on their T cell receptors (TCRs) to discern foreign antigens presented by human leukocyte antigen (HLA) proteins. The TCRs of an individual contain a record of this...
7.
Doyle L, Takushi B, Kibler R, Milles L, Orozco C, Jones J, et al.
Nat Commun
. 2023 Oct;
14(1):6746.
PMID: 37875492
De novo protein design methods can create proteins with folds not yet seen in nature. These methods largely focus on optimizing the compatibility between the designed sequence and the intended...
8.
Liu S, Bradley P, Sun W
bioRxiv
. 2023 Jun;
PMID: 37293077
T cells rely on their T cell receptors (TCRs) to recognize foreign antigens presented by human leukocyte antigen (HLA) proteins. TCRs contain a record of an individual's past immune activities,...
9.
Russell M, Simon N, Bradley P, Matsen 4th F
Elife
. 2023 May;
12.
PMID: 37227256
To appropriately defend against a wide array of pathogens, humans somatically generate highly diverse repertoires of B cell and T cell receptors (BCRs and TCRs) through a random process called...
10.
Motmaen A, Dauparas J, Baek M, Abedi M, Baker D, Bradley P
Proc Natl Acad Sci U S A
. 2023 Feb;
120(9):e2216697120.
PMID: 36802421
Peptide-binding proteins play key roles in biology, and predicting their binding specificity is a long-standing challenge. While considerable protein structural information is available, the most successful current methods use sequence...