Stefan M K Davies
Overview
Explore the profile of Stefan M K Davies including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
682
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Recent Articles
1.
Richman T, Spahr H, Ermer J, Davies S, Viola H, Bates K, et al.
Nat Commun
. 2016 Jun;
7:11884.
PMID: 27319982
The recognition and translation of mammalian mitochondrial mRNAs are poorly understood. To gain further insights into these processes in vivo, we characterized mice with a missense mutation that causes loss...
2.
Richman T, Ermer J, Davies S, Perks K, Viola H, Shearwood A, et al.
PLoS Genet
. 2015 Mar;
11(3):e1005089.
PMID: 25816300
The evolutionary divergence of mitochondrial ribosomes from their bacterial and cytoplasmic ancestors has resulted in reduced RNA content and the acquisition of mitochondria-specific proteins. The mitochondrial ribosomal protein of the...
3.
Sanchez M, Shearwood A, Chia T, Davies S, Rackham O, Filipovska A
Mol Endocrinol
. 2014 Nov;
29(1):14-27.
PMID: 25375021
Estrogens, in particular 17β-estradiol, are well-known regulators of essential cellular functions; however, discrepancies remain over the mechanisms by which they act on mitochondria. Here we propose a novel mechanism for...
4.
Viola H, Adams A, Davies S, Fletcher S, Filipovska A, Hool L
Proc Natl Acad Sci U S A
. 2014 Jun;
111(28):E2905-14.
PMID: 24969422
Duchenne muscular dystrophy is a fatal X-linked disease characterized by the absence of dystrophin. Approximately 20% of boys will die of dilated cardiomyopathy that is associated with cytoskeletal protein disarray,...
5.
Richman T, Davies S, Shearwood A, Ermer J, Scott L, Hibbs M, et al.
Nucleic Acids Res
. 2014 Mar;
42(9):5483-94.
PMID: 24598254
Mitochondrial gene expression is predominantly regulated at the post-transcriptional level and mitochondrial ribonucleic acid (RNA)-binding proteins play a key role in RNA metabolism and protein synthesis. The AU-binding homolog of...
6.
Viola H, Davies S, Filipovska A, Hool L
Am J Physiol Heart Circ Physiol
. 2013 Jan;
304(6):H767-75.
PMID: 23335798
The L-type Ca(2+) channel is the main route for calcium entry into cardiac myocytes, and it is essential for contraction. Alterations in whole cell L-type Ca(2+) channel current and Ca(2+)...
7.
Davies S, Sanchez M, Narsai R, Shearwood A, Razif M, Small I, et al.
FEBS Lett
. 2012 Jul;
586(20):3555-61.
PMID: 22841715
Mammalian pentatricopeptide repeat domain (PPR) proteins are involved in regulation of mitochondrial RNA metabolism and translation and are required for mitochondrial function. We investigated an uncharacterised PPR protein, the supernumerary...
8.
Rackham O, Shearwood A, Mercer T, Davies S, Mattick J, Filipovska A
RNA
. 2011 Oct;
17(12):2085-93.
PMID: 22028365
Human mitochondrial long noncoding RNAs (lncRNAs) have not been described to date. By analysis of deep-sequencing data we have identified three lncRNAs generated from the mitochondrial genome and confirmed their...
9.
Sanchez M, Mercer T, Davies S, Shearwood A, Nygard K, Richman T, et al.
Cell Cycle
. 2011 Aug;
10(17):2904-16.
PMID: 21857155
Mammalian mitochondrial DNA is transcribed as precursor polycistronic transcripts containing 13 mRNAs, 2 rRNAs, punctuated by 22 tRNAs. The mechanisms involved in the excision of mitochondrial tRNAs from these polycistronic...
10.
Rackham O, Shearwood A, Thyer R, McNamara E, Davies S, Callus B, et al.
Free Radic Biol Med
. 2010 Dec;
50(6):689-99.
PMID: 21172426
The cytosolic and mitochondrial thioredoxin reductases (TrxR1 and TrxR2) and thioredoxins (Trx1 and Trx2) are key components of the mammalian thioredoxin system, which is important for antioxidant defense and redox...