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Stefan Leyers

Explore the profile of Stefan Leyers including associated specialties, affiliations and a list of published articles. Areas
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Articles 4
Citations 66
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Recent Articles
1.
Hacker H, Leyers S, Wiendlocha J, Gutschow M, Wiese M
J Med Chem . 2009 Jul; 52(15):4586-95. PMID: 19580319
Four series of aromatic carboxylic acids were prepared with a urea or thiourea moiety at the neighboring position to the carboxyl group and benzene or thiophene as aromatic scaffold. Using...
2.
Ohlendorf B, Leyers S, Krick A, Kehraus S, Wiese M, Konig G
Chembiochem . 2008 Dec; 9(18):2997-3003. PMID: 19040244
Myxobacteria are gliding bacteria that belong to the delta-Proteobacteria and are known for their unique biosynthetic capabilities. Among myxobacteria, Nannocystis spp. are most closely related to marine myxobacteria and their...
3.
Leyers S, Hacker H, Wiendlocha J, Gutschow M, Wiese M
Bioorg Med Chem Lett . 2008 Aug; 18(17):4761-3. PMID: 18707884
We present a novel lead for inhibitors of multidrug resistance-associated proteins (MRPs). Compound 1 (4-[(5,6,7,8-tetrahydro-4-oxo-4H-[1]benzothieno[2,3-d][1,3]thiazin-2-yl)amino]benzoic acid) was about six times more potent than the known inhibitor MK571 at MRP1, while...
4.
Zisowsky J, Koegel S, Leyers S, Devarakonda K, Kassack M, Osmak M, et al.
Biochem Pharmacol . 2006 Nov; 73(2):298-307. PMID: 17097621
Platinum sensitivity and platinum resistance may involve altered activity of transport proteins. In order to assess the role of drug uptake and efflux in this phenomenon, we compared the expression...