Stefan Christen
Overview
Explore the profile of Stefan Christen including associated specialties, affiliations and a list of published articles.
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36
Citations
2611
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Recent Articles
1.
Levy T, Voeltzke K, Hruby L, Alasad K, Bas Z, Snaebjornsson M, et al.
Nat Commun
. 2024 May;
15(1):4083.
PMID: 38744825
Energetic stress compels cells to evolve adaptive mechanisms to adjust their metabolism. Inhibition of mTOR kinase complex 1 (mTORC1) is essential for cell survival during glucose starvation. How mTORC1 controls...
2.
Membrez M, Migliavacca E, Christen S, Yaku K, Trieu J, Lee A, et al.
Nat Metab
. 2024 Mar;
6(3):433-447.
PMID: 38504132
Mitochondrial dysfunction and low nicotinamide adenine dinucleotide (NAD) levels are hallmarks of skeletal muscle ageing and sarcopenia, but it is unclear whether these defects result from local changes or can...
3.
Schreder T, Borbely Y, Christen S, Wiest R, Raber L, Gunther G
Respirol Case Rep
. 2023 Dec;
12(1):e01244.
PMID: 38045823
Acquired tracheo-oesophageal fistulas (TEFs) are rare and challenging complications in the course of oesophageal cancer. While surgery is the only curative treatment option for TEFs many patients are not eligible...
4.
Phillips E, Balss J, Bethke F, Pusch S, Christen S, Hielscher T, et al.
Oncogenesis
. 2022 Sep;
11(1):57.
PMID: 36115843
Glioblastoma is a highly aggressive brain tumor for which there is no cure. The metabolic enzyme 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4 (PFKFB4) is essential for glioblastoma stem-like cell (GSC) survival but its mode...
5.
Sanders M, Ratinaud Y, Neopane K, Bonhoure N, Day E, Ciclet O, et al.
J Biol Chem
. 2022 Mar;
298(5):101852.
PMID: 35331736
AMP-activated protein kinase (AMPK) is a central energy sensor that coordinates the response to energy challenges to maintain cellular ATP levels. AMPK is a potential therapeutic target for treating metabolic...
6.
Giner M, Christen S, Bartova S, Makarov M, Migaud M, Canto C, et al.
Int J Mol Sci
. 2021 Oct;
22(19).
PMID: 34638936
Nicotinamide adenine dinucleotide (NAD) and its reduced form (NADH) are coenzymes employed in hundreds of metabolic reactions. NAD also serves as a substrate for enzymes such as sirtuins, poly(ADP-ribose) polymerases...
7.
Gut P, Matilainen S, Meyer J, Pallijeff P, Richard J, Carroll C, et al.
Nat Commun
. 2020 Nov;
11(1):5927.
PMID: 33230181
Mitochondrial acyl-coenzyme A species are emerging as important sources of protein modification and damage. Succinyl-CoA ligase (SCL) deficiency causes a mitochondrial encephalomyopathy of unknown pathomechanism. Here, we show that succinyl-CoA...
8.
Chareyron I, Christen S, Moco S, Valsesia A, Lassueur S, Dayon L, et al.
Diabetologia
. 2020 Sep;
63(12):2628-2640.
PMID: 32960311
Aims/hypothesis: In islets from individuals with type 2 diabetes and in islets exposed to chronic elevated glucose, mitochondrial energy metabolism is impaired. Here, we studied early metabolic changes and mitochondrial...
9.
SLC25A32 sustains cancer cell proliferation by regulating flavin adenine nucleotide (FAD) metabolism
Santoro V, Kovalenko I, Vriens K, Christen S, Bernthaler A, Haegebarth A, et al.
Oncotarget
. 2020 Mar;
11(8):801-812.
PMID: 32166001
SLC25A32 is a member of the solute carrier 25 family of mitochondrial transporters. SLC25A32 transports tetrahydrofolate (THF) as well as FAD into mitochondria and regulates mitochondrial one-carbon metabolism and redox...
10.
Maubach J, Christen S, Macpherson A, Worni M
VideoGIE
. 2019 Apr;
4(4):169-171.
PMID: 31032466
No abstract available.