Stefan A Hoyng
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Explore the profile of Stefan A Hoyng including associated specialties, affiliations and a list of published articles.
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10
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776
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Recent Articles
1.
Timed GDNF gene therapy using an immune-evasive gene switch promotes long distance axon regeneration
Eggers R, de Winter F, Hoyng S, Hoeben R, Malessy M, Tannemaat M, et al.
Brain
. 2019 Jan;
142(2):295-311.
PMID: 30649249
Neurosurgical repair in patients with proximal nerve lesions results in unsatisfactory recovery of function. Gene therapy for neurotrophic factors is a powerful strategy to promote axon regeneration. Glial cell line-derived...
2.
Verhaagen J, Hobo B, Ehlert E, Eggers R, Korecka J, Hoyng S, et al.
Methods Mol Biol
. 2017 Dec;
1715:3-17.
PMID: 29188502
Adeno-associated viral vectors have numerous applications in neuroscience, including the study of gene function in health and disease, targeting of light-sensitive proteins to anatomically distinct sets of neurons to manipulate...
3.
Hoyng S, de Winter F, Tannemaat M, Blits B, Malessy M, Verhaagen J
Front Mol Neurosci
. 2015 Aug;
8:32.
PMID: 26236188
Clinical phase I/II studies have demonstrated the safety of gene therapy for a variety of central nervous system disorders, including Canavan's, Parkinson's (PD) and Alzheimer's disease (AD), retinal diseases and...
4.
Pellissier L, Hoek R, Vos R, Aartsen W, Klimczak R, Hoyng S, et al.
Mol Ther Methods Clin Dev
. 2015 May;
1:14009.
PMID: 26015954
Despite their physiological roles, Müller glial cells are involved directly or indirectly in retinal disease pathogenesis and are an interesting target for therapeutic approaches for retinal diseases and regeneration such...
5.
Datema M, Appelman-Dijkstra N, Hoyng S, Verstegen M, Koot R
Acta Neurochir (Wien)
. 2015 May;
157(7):1215-8.
PMID: 25976340
A 28-year-old man with genetically confirmed hyperostosis corticalis generalisata (Van Buchem disease) suffered from headache and progressive cognitive and sensibility disorders. Bone formation of the skull was ongoing, leading to...
6.
Hoyng S, de Winter F, Gnavi S, de Boer R, Boon L, Korvers L, et al.
Exp Neurol
. 2014 Aug;
261:578-93.
PMID: 25128265
The clinical outcome of microsurgical repair of an injured peripheral nerve with an autograft is suboptimal. A key question addressed here is: can axon regeneration through an autograft be further...
7.
Eggers R, de Winter F, Hoyng S, Roet K, Ehlert E, Malessy M, et al.
PLoS One
. 2013 Aug;
8(8):e71076.
PMID: 23951085
Although the peripheral nerve is capable of regeneration, only a small minority of patients regain normal function after surgical reconstruction of a major peripheral nerve lesion, resulting in a severe...
8.
Shakhbazau A, Kawasoe J, Hoyng S, Kumar R, van Minnen J, Verhaagen J, et al.
Mol Cell Neurosci
. 2012 Jun;
50(1):103-12.
PMID: 22735691
Peripheral nerve injury leads to a rapid and robust increase in the synthesis of neurotrophins which guide and support regenerating axons. To further optimize neurotrophin supply at the earliest stages...
9.
Yu P, Deng D, Beppu H, Hong C, Lai C, Hoyng S, et al.
J Biol Chem
. 2007 Nov;
283(7):3877-88.
PMID: 18042551
Bone morphogenetic protein (BMP) signals regulate the growth and differentiation of diverse lineages. The association of mutations in the BMP type II receptor (BMPRII) with idiopathic pulmonary arterial hypertension suggests...
10.
Yu P, Hong C, Sachidanandan C, Babitt J, Deng D, Hoyng S, et al.
Nat Chem Biol
. 2007 Nov;
4(1):33-41.
PMID: 18026094
Bone morphogenetic protein (BMP) signals coordinate developmental patterning and have essential physiological roles in mature organisms. Here we describe the first known small-molecule inhibitor of BMP signaling-dorsomorphin, which we identified...