Stanley J Watowich
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Explore the profile of Stanley J Watowich including associated specialties, affiliations and a list of published articles.
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41
Citations
790
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Recent Articles
11.
Neelakantan H, Wang H, Vance V, Hommel J, McHardy S, Watowich S
J Med Chem
. 2017 May;
60(12):5015-5028.
PMID: 28548833
Nicotinamide N-methyltransferase (NNMT) is a fundamental cytosolic biotransforming enzyme that catalyzes the N-methylation of endogenous and exogenous xenobiotics. We have identified small molecule inhibitors of NNMT with >1000-fold range of...
12.
Langsjoen R, Auguste A, Rossi S, Roundy C, Penate H, Kastis M, et al.
Antiviral Res
. 2017 May;
143:246-251.
PMID: 28461071
Alphaviruses require conserved cysteine residues for proper folding and assembly of the E1 and E2 envelope glycoproteins, and likely depend on host protein disulfide isomerase-family enzymes (PDI) to aid in...
13.
Neelakantan H, Vance V, Wang H, McHardy S, Watowich S
Biochemistry
. 2017 Jan;
56(6):824-832.
PMID: 28121423
Nicotinamide N-methyltransferase (NNMT) is an important biotransforming enzyme that catalyzes the transfer of a labile methyl group from the ubiquitous cofactor S-5'-adenosyl-l-methionine (SAM) to endogenous and exogenous small molecules to...
14.
Ochoa R, Watowich S, Florez A, Mesa C, Robledo S, Muskus C
J Comput Aided Mol Des
. 2016 Jul;
30(7):541-52.
PMID: 27438595
The trypanosomatid protozoa Leishmania is endemic in ~100 countries, with infections causing ~2 million new cases of leishmaniasis annually. Disease symptoms can include severe skin and mucosal ulcers, fever, anemia,...
15.
Viswanathan U, Tomlinson S, Fonner J, Mock S, Watowich S
J Chem Inf Model
. 2014 Sep;
54(10):2816-25.
PMID: 25263519
We report the discovery of a novel small-molecule inhibitor of the dengue virus (DENV) protease (NS2B-NS3pro) using a newly constructed Web-based portal (DrugDiscovery@TACC) for structure-based virtual screening. Our drug discovery...
16.
Garces A, Watowich S
Biochemistry
. 2013 Sep;
52(39):6856-65.
PMID: 24015950
West Nile virus (WNV) is a mosquito-borne flavivirus with a rapidly expanding global distribution. Infection can cause severe neurological disease and fatality in humans. Efforts are ongoing to develop antiviral...
17.
Rusu M, Bonneau R, Holbrook M, Watowich S, Birmanns S, Wriggers W, et al.
Front Microbiol
. 2012 Jul;
3:254.
PMID: 22837754
Rift Valley fever virus (RVFV) is a bunyavirus endemic to Africa and the Arabian Peninsula that infects humans and livestock. The virus encodes two glycoproteins, Gn and Gc, which represent...
18.
Tomlinson S, Watowich S
Antiviral Res
. 2011 Dec;
93(2):245-252.
PMID: 22193283
Dengue virus (DENV), a mosquito-borne member of the family Flaviviridae, is a significant global pathogen affecting primarily tropical and subtropical regions of the world and placing tremendous burden on the...
19.
Sherman M, Freiberg A, Razmus D, Yazuka S, Koht C, Hilser V, et al.
Appl Biosaf
. 2011 Aug;
15(3):130-136.
PMID: 21852942
This article describes a unique cryo-electron microscopy (CryoEM) facility to study the three-dimensional organization of viruses at biological safety level 3 (BSL-3). This facility, the W. M. Keck Center for...
20.
Malmstrom R, Watowich S
J Chem Inf Model
. 2011 Jun;
51(7):1648-55.
PMID: 21696204
Virtual screening of small molecule databases against macromolecular targets was used to identify binding ligands and predict their lowest energy bound conformation (i.e., pose). AutoDock4-generated poses were rescored using mean-field...