Stanley A Thayer
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Explore the profile of Stanley A Thayer including associated specialties, affiliations and a list of published articles.
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54
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1156
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Recent Articles
1.
NMDA Receptor-Mediated Ca Flux Attenuated by the NMDA Receptor/TRPM4 Interface Inhibitor Brophenexin
Casby J, Gansemer B, Thayer S
Pharmacol Res Perspect
. 2024 Nov;
12(6):e70038.
PMID: 39574295
Transient receptor potential melastatin-4 (TRPM4) forms a complex with N-methyl-D-aspartate receptors (NMDARs) that facilitates NMDAR-mediated neurotoxicity. Here we used pharmacological tools to determine how TRPM4 regulates NMDAR signaling. Brophenexin, a...
2.
Luo H, Marron Fernandez de Velasco E, Gansemer B, Frederick M, Aguado C, Lujan R, et al.
Sci Signal
. 2024 Oct;
17(856):eado4132.
PMID: 39353038
Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by amyloid plaques and cognitive decline, the latter of which is thought to be driven by soluble oligomeric amyloid-β (oAβ). The...
3.
Ewens A, Pilski A, Hastings S, Krook-Magnuson C, Graves S, Krook-Magnuson E, et al.
J Pharmacol Exp Ther
. 2024 Jul;
391(1):104-118.
PMID: 39060163
Human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND) affects nearly half of the 39 million people living with HIV. HAND symptoms range from subclinical cognitive impairment to dementia; the mechanisms that...
4.
McMullan H, Gansemer B, Thayer S
Front Pharmacol
. 2024 Mar;
15:1369757.
PMID: 38533258
Antiretroviral (ARV) drugs have improved prognoses for people living with HIV. However, HIV-associated neurocognitive disorders (HAND) persist despite undetectable viral loads. Some ARVs have been linked to neuropsychiatric effects that...
5.
Asher M, McMullan H, Dong A, Li Y, Thayer S
Mol Pharmacol
. 2022 Nov;
103(2):100-112.
PMID: 36379717
The endocannabinoid system (ECS) modulates synaptic function to regulate many aspects of neurophysiology. It adapts to environmental changes and is affected by disease. Thus, the ECS presents an important target...
6.
Rienecker K, Poston R, Segales J, Finholm I, Sono M, Munteanu S, et al.
J Biol Chem
. 2022 Jul;
298(9):102278.
PMID: 35863435
Immediate early genes (IEGs) are transcribed in response to neuronal activity from sensory stimulation during multiple adaptive processes in the brain. The transcriptional profile of IEGs is indicative of the...
7.
Wu M, Thayer S
eNeuro
. 2020 May;
7(3).
PMID: 32471847
Despite the success of antiretroviral therapy in suppressing viral load, nearly half of the 37 million people infected with HIV experience cognitive and motor impairments, collectively classified as HIV-associated neurocognitive...
8.
Green M, Pengo T, Raybuck J, Naqvi T, McMullan H, Hawkinson J, et al.
Front Cell Neurosci
. 2019 Nov;
13:467.
PMID: 31680875
Synapse loss and dendritic damage correlate with cognitive decline in many neurodegenerative diseases, underlie neurodevelopmental disorders, and are associated with environmental and drug-induced CNS toxicities. However, screening assays designed to...
9.
Wu M, Zhang X, Asher M, Thayer S
Brain Res
. 2019 Sep;
1724:146467.
PMID: 31539547
HIV-associated neurocognitive disorder (HAND) affects nearly half of all HIV-infected individuals. Synaptodendritic damage correlates with neurocognitive decline in HAND, and many studies have demonstrated that HIV-induced neuronal injury results from...
10.
Green M, Thayer S
Neuropharmacology
. 2019 Feb;
149:161-168.
PMID: 30797029
HIV-Associated Neurocognitive disorder (HAND) affects nearly half of infected patients. The HIV envelope protein gp120 is shed by infected cells and is a potent neurotoxin in vitro that reproduces many...