Sriram Subramaniam
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Explore the profile of Sriram Subramaniam including associated specialties, affiliations and a list of published articles.
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182
Citations
7976
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Recent Articles
1.
Mannar D, Saville J, Poloni C, Zhu X, Bezeruk A, Tidey K, et al.
Nat Commun
. 2024 Feb;
15(1):1854.
PMID: 38424106
The XBB.1.5 variant of SARS-CoV-2 has rapidly achieved global dominance and exhibits a high growth advantage over previous variants. Preliminary reports suggest that the success of XBB.1.5 stems from mutations...
2.
Kleywegt G, Adams P, Butcher S, Lawson C, Rohou A, Rosenthal P, et al.
IUCrJ
. 2024 Feb;
11(Pt 2):140-151.
PMID: 38358351
In January 2020, a workshop was held at EMBL-EBI (Hinxton, UK) to discuss data requirements for the deposition and validation of cryoEM structures, with a focus on single-particle analysis. The...
3.
Marcus K, Huang Y, Subramanian S, Gee C, Gorday K, Ghaffari-Kashani S, et al.
Nat Struct Mol Biol
. 2024 Jan;
31(3):424-435.
PMID: 38177685
Clamp loaders are AAA+ ATPases that facilitate high-speed DNA replication. In eukaryotic and bacteriophage clamp loaders, ATP hydrolysis requires interactions between aspartate residues in one protomer, present in conserved 'DEAD-box'...
4.
Kleywegt G, Adams P, Butcher S, Lawson C, Rohou A, Rosenthal P, et al.
ArXiv
. 2023 Dec;
PMID: 38076521
In January 2020, a workshop was held at EMBL-EBI (Hinxton, UK) to discuss data requirements for deposition and validation of cryoEM structures, with a focus on single-particle analysis. The meeting...
5.
6.
Mannar D, Ahmed S, Subramaniam S
Curr Opin Cell Biol
. 2023 Dec;
86:102291.
PMID: 38056141
AAA ATPases are a conserved group of enzymes that couple ATP hydrolysis to diverse activities critical for cellular homeostasis by targeted protein-protein interactions. Some of these interactions are potential therapeutic...
7.
Halvorson T, Ivison S, Huang Q, Ladua G, Yotis D, Mannar D, et al.
Transplantation
. 2023 Nov;
108(4):e49-e62.
PMID: 38012843
Background: Immune-suppressed solid-organ transplant recipients (SOTRs) display impaired humoral responses to COVID-19 vaccination, but T cell responses are incompletely understood. SARS-CoV-2 variants Omicron BA.4/5 (BA.4/5) and XBB.1.5 escape neutralization by...
8.
Castells-Graells R, Meador K, Arbing M, Sawaya M, Gee M, Cascio D, et al.
Proc Natl Acad Sci U S A
. 2023 Sep;
120(37):e2305494120.
PMID: 37669364
Cryoelectron microscopy (Cryo-EM) has enabled structural determination of proteins larger than about 50 kDa, including many intractable by any other method, but it has largely failed for smaller proteins. Here,...
9.
Gandhy S, Casak S, Mushti S, Cheng J, Subramaniam S, Zhao H, et al.
Clin Cancer Res
. 2023 Jun;
29(20):4027-4031.
PMID: 37289037
On September 30, 2022, the FDA granted accelerated approval to futibatinib for the treatment of adult patients with previously treated, unresectable, locally advanced or metastatic intrahepatic cholangiocarcinoma (iCCA) with FGFR2...
10.
Cholak S, Saville J, Zhu X, Berezuk A, Tuttle K, Haji-Ghassemi O, et al.
Structure
. 2023 May;
31(7):790-800.e4.
PMID: 37192614
The coordinated release of Ca from the sarcoplasmic reticulum (SR) is critical for excitation-contraction coupling. This release is facilitated by ryanodine receptors (RyRs) that are embedded in the SR membrane....