Srikanth Manam
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Explore the profile of Srikanth Manam including associated specialties, affiliations and a list of published articles.
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Articles
11
Citations
133
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Recent Articles
1.
Murthy A, Wright-McAfee E, Warda K, Moy L, Bui N, Musunuri T, et al.
Pathog Dis
. 2024 Apr;
82.
PMID: 38684476
We have demonstrated previously that TNF-α-producing CD8+ T cells mediate chlamydial pathogenesis, likely in an antigen (Ag)-specific fashion. Here we hypothesize that inhibition of Ag-specific CD8+ T cell response after...
2.
Seleem M, Wood N, Brinkworth A, Manam S, Carabeo R, Murthy A, et al.
ACS Infect Dis
. 2021 Dec;
8(1):227-241.
PMID: 34935346
is the leading pathogen in sexually transmitted bacterial infections across the globe. The development of a selective treatment against this pathogen could be an attractive therapeutic option that will reduce...
3.
Zafiratos M, Cottrell J, Manam S, Henderson K, Ramsey K, Murthy A
Microbes Infect
. 2018 Oct;
21(2):104-108.
PMID: 30292879
The host immune responses that mediate Chlamydia-induced chronic disease sequelae are incompletely understood. The role of TNF-α, TNF receptor 1 (TNFR1), and TNF receptor 2 (TNFR2), in Chlamydia pneumoniae (CPN)-induced...
4.
Sigar I, Schripsema J, Kelly K, Murthy A, Manam S, Ramsey K
BMC Res Notes
. 2018 Jun;
11(1):361.
PMID: 29880030
Objective: This study aims to eliminate Mycoplasma spp. contamination from laboratory stocks of Chlamydia spp. by in vivo passage or by plaque assay. Results: We have described two methods of...
5.
Vlcek K, Li W, Manam S, Zanotti B, Nicholson B, Ramsey K, et al.
Immunol Cell Biol
. 2015 Sep;
94(2):208-12.
PMID: 26323581
Genital chlamydial infections lead to severe upper reproductive tract pathology in a subset of untreated women. We demonstrated previously that tumor necrosis factor (TNF)-α-producing CD8(+) T cells contribute significantly to...
6.
Zafiratos M, Manam S, Henderson K, Ramsey K, Murthy A
Pathog Dis
. 2015 Jul;
73(7).
PMID: 26220574
Chlamydia pneumoniae is a community-acquired bacterial pathogen that has been strongly associated with exacerbation of atherosclerosis. We evaluated the role of CD8(+) T cells in the C57BL/6J mouse model of...
7.
Manam S, Thomas J, Li W, Maladore A, Schripsema J, Ramsey K, et al.
J Infect Dis
. 2015 Jan;
211(12):2014-22.
PMID: 25552370
Background: We demonstrated previously that tumor necrosis factor α (TNF-α)-producing Chlamydia-specific CD8(+) T cells cause oviduct pathological sequelae. Methods: In the current study, we used wild-type C57BL/6J (WT) mice with...
8.
Manam S, Chaganty B, Evani S, Zafiratos M, Ramasubramanian A, Arulanandam B, et al.
PLoS One
. 2013 Jun;
8(5):e64917.
PMID: 23741420
Chlamydia trachomatis is the most common bacterial sexually transmitted disease in the world and specifically in the United States, with the highest incidence in age-groups 14-19 years. In a subset...
9.
Manam S, Nicholson B, Murthy A
Pathog Dis
. 2013 Apr;
67(3):221-4.
PMID: 23620186
Chlamydia trachomatis is the most common bacterial sexually transmitted disease worldwide and leads to serious pathological sequelae in the upper genital tract (UGT) including pelvic inflammatory disease, ectopic pregnancy, and...
10.
Nallaparaju K, Yu J, Rodriguez S, Zogaj X, Manam S, Guentzel M, et al.
PLoS One
. 2011 Apr;
6(3):e18201.
PMID: 21483828
Background: Francisella tularensis is a Gram-negative facultative intracellular bacterium and the causative agent of the lethal disease tularemia. An outer membrane protein (FTT0918) of F. tularensis subsp. tularensis has been...