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Sowmya Bekshe Lokappa

Explore the profile of Sowmya Bekshe Lokappa including associated specialties, affiliations and a list of published articles. Areas
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Articles 13
Citations 190
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Recent Articles
1.
Lokappa S, Cornwall M, Chen J
Bio Protoc . 2021 Mar; 9(14):e3300. PMID: 33654813
Rhodopsin is a G-protein coupled receptor (GPCR) that mediates vision under dim light. Upon light exposure, rhodopsin is phosphorylated at multiple serine and threonine sites at its carboxyl-terminus by rhodopsin...
2.
Silverman D, Chai Z, Yue W, Ramisetty S, Lokappa S, Sakai K, et al.
Proc Natl Acad Sci U S A . 2020 Sep; 117(37):23033-23043. PMID: 32873651
Numerous rhodopsin mutations have been implicated in night blindness and retinal degeneration, often with unclear etiology. D190N-rhodopsin (D190N-Rho) is a well-known inherited human mutation causing retinitis pigmentosa. Both higher-than-normal spontaneous-isomerization...
3.
Mohapatra A, Lokappa S, Chaudhary N
Biochem Biophys Res Commun . 2019 Nov; 521(3):732-738. PMID: 31706570
The organization of caveolae ultrastructures in the plasma membrane and the functions they dictate are mediated by membrane-embedded caveolins (caveolin-1, 2, 3) and peripherally attached cavins (cavin-1, 2, 3, 4)....
4.
George G, Parambath S, Lokappa S, Varkey J
Gene . 2019 Feb; 697:67-77. PMID: 30776463
Background: Parkinson's disease (PD) is a complex neurodegenerative movement disorder that primarily results due to the loss of dopaminergic neurons in the substantia nigra region. Studying gene expression in the...
5.
George G, Singh S, Lokappa S, Varkey J
Genomics . 2018 Jun; 111(4):819-830. PMID: 29852216
Parkinson's disease (PD) is a neurodegenerative disorder involving progressive deterioration of dopaminergic neurons. Although few genetic markers for familial PD are known, the etiology of sporadic PD remains poorly understood....
6.
Lokappa S, Chandrababu K, Moradian-Oldak J
Biochem Biophys Res Commun . 2015 Jul; 464(3):956-61. PMID: 26188506
We have recently reported that the extracellular enamel protein amelogenin has affinity to interact with phospholipids and proposed that such interactions may play key roles in enamel biomineralization as well...
7.
Lokappa S, Chandrababu K, Dutta K, Perovic I, Evans J, Moradian-Oldak J
Biopolymers . 2014 Oct; 103(2):96-108. PMID: 25298002
Amelogenin protein has the potential to interact with other enamel matrix proteins, mineral, and cell surfaces. We investigated the interactions of recombinant amelogenin rP172 with small unilamellar vesicles as model...
8.
Mazumder P, Prajapati S, Lokappa S, Gallon V, Moradian-Oldak J
Front Physiol . 2014 Aug; 5:274. PMID: 25120489
Epithelially-derived ameloblasts secrete extracellular matrix proteins including amelogenin, enamelin, and ameloblastin. Complex intermolecular interactions among these proteins are believed to be important in controlling enamel formation. Here we provide in...
9.
Chandrababu K, Dutta K, Lokappa S, Ndao M, Evans J, Moradian-Oldak J
Biopolymers . 2013 Oct; 101(5):525-35. PMID: 24114119
Amelogenin, the major extracellular matrix protein of developing tooth enamel is intrinsically disordered. Through its interaction with other proteins and mineral, amelogenin assists enamel biomineralization by controlling the formation of...
10.
Lokappa S, Nagaraj R
J Pept Sci . 2012 Oct; 18(11):696-703. PMID: 23027578
Caveolin-1 has an atypical membrane-spanning domain comprising of 34 residues. Caveolin-1 targets to lipid droplets under certain conditions, where they are involved in signaling and cholesterol balance. In the present...