Sophia Tsoka
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Explore the profile of Sophia Tsoka including associated specialties, affiliations and a list of published articles.
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67
Citations
1983
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Recent Articles
1.
Grandits M, Palhares L, Osborn G, Chauhan J, Stoker K, Sow H, et al.
J Immunother Cancer
. 2025 Mar;
13(3).
PMID: 40074330
Background: Anti-human epidermal growth factor receptor 2 (HER2) IgG1-based antibody therapies significantly improve cancer prognosis, yet intrinsic or acquired resistance to fragment antigen-binding (Fab)-mediated direct effects commonly occurs. Most resistant...
2.
Stavraka C, Chauhan J, Crescioli S, McSweeney S, Pope A, Gillett C, et al.
Allergy
. 2025 Mar;
PMID: 40045925
Background: IgE antibodies directed against cancer antigens have demonstrated potent anti-tumour effects in pre-clinical studies. MOv18 IgE, the first-in-class IgE recognising the cancer antigen folate receptor alpha (FRα), showed preliminary...
3.
Liapis G, Tsoka S, Papageorgiou L
Mach Learn
. 2025 Feb;
114(3):51.
PMID: 40017483
Data classification is considered a fundamental research subject within the machine learning community. Researchers seek the improvement of machine learning algorithms in not only accuracy, but also interpretability. Interpretable algorithms...
4.
Maiques O, Sallan M, Laddach R, Pandya P, Varela A, Crosas-Molist E, et al.
Nat Commun
. 2025 Feb;
16(1):1394.
PMID: 39952917
The extracellular matrix (ECM) controls tumour dissemination. We characterise ECM organization in human and mouse tumours, identifying three regions: tumour body, proximal invasive front and distal invasive front. Invasive areas...
5.
Palhares L, Grandits M, Stoker K, Chauhan J, Sow H, Fruhwirth G, et al.
J Exp Clin Cancer Res
. 2025 Feb;
44(1):49.
PMID: 39934835
Background: Tumor-targeting IgE antibodies have elicited potent tumor-restricting effects by recruiting immune effector mechanisms. However, a dedicated platform for the generation, selection and evaluation of novel IgEs based on target...
6.
Li Y, Avelar P, Chen X, Zhang L, Wu M, Tsoka S
Bioinformatics
. 2024 Sep;
40(Suppl 2):ii62-ii69.
PMID: 39230708
Motivation: A key challenge in deep generative models for molecular design is to navigate random sampling of the vast molecular space, and produce promising molecules that strike a balance across...
7.
Cheung A, Chenoweth A, Johansson A, Laddach R, Guppy N, Trendell J, et al.
Clin Cancer Res
. 2024 May;
30(15):3298-3315.
PMID: 38772416
Purpose: Anti-EGFR antibodies show limited response in breast cancer, partly due to activation of compensatory pathways. Furthermore, despite the clinical success of cyclin-dependent kinase (CDK) 4/6 inhibitors in hormone receptor-positive...
8.
Li Y, Cardoso-Silva J, Kelly J, Delves M, Furnham N, Papageorgiou L, et al.
Artif Intell Med
. 2024 Jan;
147:102700.
PMID: 38184363
Background: The search for new antimalarial treatments is urgent due to growing resistance to existing therapies. The Open Source Malaria (OSM) project offers a promising starting point, having extensively screened...
9.
OShea R, Manickavasagar T, Horst C, Hughes D, Cusack J, Tsoka S, et al.
Insights Imaging
. 2023 Nov;
14(1):195.
PMID: 37980637
Purpose: Interpretability is essential for reliable convolutional neural network (CNN) image classifiers in radiological applications. We describe a weakly supervised segmentation model that learns to delineate the target object, trained...
10.
Lui P, Ainali C, Chu C, Terranova-Barberio M, Karagiannis P, Tewari A, et al.
iScience
. 2023 Oct;
26(10):108029.
PMID: 37860766
Skin immune homeostasis is a multi-faceted process where dermal dendritic cells (DDCs) are key in orchestrating responses to environmental stressors. We have previously identified CD141CD14 DDCs as a skin-resident immunoregulatory...