Sook Hyun Chung
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Explore the profile of Sook Hyun Chung including associated specialties, affiliations and a list of published articles.
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20
Citations
295
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Recent Articles
1.
Sin T, Tng N, Dragoli J, Ramesh Kumar S, Villafuerte-Trisolini C, Chung S, et al.
Mol Ther
. 2024 Sep;
PMID: 39342431
CRISPR-based genome editing enables permanent suppression of angiogenic factors such as vascular endothelial growth factor (VEGF) as a potential treatment for choroidal neovascularization (CNV)-a major cause of blindness in age-related...
2.
Sin T, Kim S, Li Y, Wang J, Chen R, Chung S, et al.
Invest Ophthalmol Vis Sci
. 2023 Jan;
64(1):18.
PMID: 36689233
Purpose: Foveoschisis involves the pathologic splitting of retinal layers at the fovea, which may occur congenitally in X-linked retinoschisis (XLRS) or as an acquired complication of myopia. XLRS is attributed...
3.
Chung S, Sin T, Dang B, Ngo T, Lo T, Lent-Schochet D, et al.
Mol Ther Nucleic Acids
. 2022 May;
28:613-622.
PMID: 35614998
Clustered regularly interspaced short palindromic repeats (CRISPR)-based genomic disruption of vascular endothelial growth factor A () with a single gRNA suppresses choroidal neovascularization (CNV) in preclinical studies, offering the prospect...
4.
Chung S, Sin T, Ngo T, Yiu G
Front Genome Ed
. 2021 Oct;
2:594984.
PMID: 34713223
Among genome engineering tools, Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-based approaches have been widely adopted for translational studies due to their robustness, precision, and ease of use. When delivered...
5.
Chung S, Mollhoff I, Mishra A, Sin T, Ngo T, Ciulla T, et al.
Hum Gene Ther
. 2021 Jan;
32(13-14):682-693.
PMID: 33446041
The suprachoroid is a potential space located between the sclera and choroid of the eye, which provides a novel route for ocular drug or viral vector delivery. Suprachoroidal injection of...
6.
Tran T, Kim S, Lin K, Chung S, Park S, Sazhnyev Y, et al.
Invest Ophthalmol Vis Sci
. 2020 Jul;
61(8):16.
PMID: 32663290
Purpose: To employ quantitative fundus autofluorescence (qAF) imaging in rhesus macaques to noninvasively assess retinal pigment epithelial (RPE) lipofuscin in nonhuman primates (NHPs) as a model of aging and age-related...
7.
Chung S, Mollhoff I, Nguyen U, Nguyen A, Stucka N, Tieu E, et al.
Mol Ther Methods Clin Dev
. 2020 Mar;
17:409-417.
PMID: 32128346
Frequent injections of anti-vascular endothelial growth factor (anti-VEGF) agents are a clinical burden for patients with neovascular age-related macular degeneration (AMD). Genomic disruption of using adeno-associated viral (AAV) delivery of...
8.
Yiu G, Chung S, Mollhoff I, Wang Y, Nguyen U, Shibata B, et al.
Invest Ophthalmol Vis Sci
. 2020 Feb;
61(2):32.
PMID: 32084273
Purpose: To characterize the evolution and structure of soft drusen in aged rhesus macaques using in vivo multimodal retinal imaging and ex vivo histologic and ultrastructural analyses as a nonhuman...
9.
Yiu G, Chung S, Mollhoff I, Nguyen U, Thomasy S, Yoo J, et al.
Mol Ther Methods Clin Dev
. 2020 Feb;
16:179-191.
PMID: 32055646
Retinal gene therapy using adeno-associated viruses (AAVs) is constrained by the mode of viral vector delivery. Intravitreal AAV injections are impeded by the internal limiting membrane barrier, while subretinal injections...
10.
Chung S, Shen W, Davidson K, Pebay A, Wong R, Yau B, et al.
Front Cell Neurosci
. 2019 Dec;
13:527.
PMID: 31849614
Dysfunction of retinal glial cells, particularly Müller cells, has been implicated in several retinal diseases. Despite their important contribution to retinal homeostasis, a specific way to differentiate retinal glial cells...