Sonya James
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Explore the profile of Sonya James including associated specialties, affiliations and a list of published articles.
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22
Citations
533
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Recent Articles
11.
Oldham R, Mockridge C, James S, Duriez P, Chan H, Cox K, et al.
J Immunother Cancer
. 2020 Jun;
8(1).
PMID: 32554613
Background: Immune compromised mice are increasingly used for the preclinical development of monoclonal antibodies (mAb). Most common are non-obese diabetic (NOD) severe combined immunodeficient (SCID) and their derivatives such as...
12.
Buchan S, Dou L, Remer M, Booth S, Dunn S, Lai C, et al.
Immunity
. 2018 Nov;
49(5):958-970.e7.
PMID: 30446386
The costimulatory receptor 4-1BB is expressed on activated immune cells, including activated T cells. Antibodies targeting 4-1BB enhance the proliferation and survival of antigen-stimulated T cells in vitro and promote...
13.
Turaj A, Hussain K, Cox K, Rose-Zerilli M, Testa J, Dahal L, et al.
Cancer Cell
. 2017 Dec;
32(6):777-791.e6.
PMID: 29198913
Monoclonal antibodies (mAbs) can destroy tumors by recruiting effectors such as myeloid cells, or targeting immunomodulatory receptors to promote cytotoxic T cell responses. Here, we examined the therapeutic potential of...
14.
Development and Characterization of Monoclonal Antibodies Specific for Mouse and Human Fcγ Receptors
Tutt A, James S, Laversin S, Tipton T, Ashton-Key M, French R, et al.
J Immunol
. 2015 Oct;
195(11):5503-16.
PMID: 26512139
FcγRs are key regulators of the immune response, capable of binding to the Fc portion of IgG Abs and manipulating the behavior of numerous cell types. Through a variety of...
15.
Williams E, Dunn S, James S, Johnson P, Cragg M, Glennie M, et al.
Clin Cancer Res
. 2013 May;
19(13):3545-55.
PMID: 23649004
Purpose: Neuroblastoma is one of the commonest extracranial tumors of childhood. The majority of patients present with metastatic disease for which outcome remains poor. Immunotherapy is an attractive therapeutic approach...
16.
Buchan S, Taraban V, Slebioda T, James S, Cunningham A, Al-Shamkhani A
Eur J Immunol
. 2012 Jan;
42(3):580-8.
PMID: 22259035
The TNF receptor superfamily member death receptor 3 (DR3) exacerbates Th2- and Th17-cell-mediated inflammatory and autoimmune conditions, yet no role in host defence has been reported. Here, we examined the...
17.
Moller A, Xie S, Hosp F, Lang B, Phatnani H, James S, et al.
Mol Cell Proteomics
. 2011 Dec;
11(6):M111.011767.
PMID: 22199231
RNA polymerase II (RNAPII) transcribes protein-coding genes in eukaryotes and interacts with factors involved in chromatin remodeling, transcriptional activation, elongation, and RNA processing. Here, we present the isolation of native...
18.
White A, Tutt A, James S, Wilkinson K, Castro F, Dixon S, et al.
Immunology
. 2010 May;
131(1):141-51.
PMID: 20465572
In this study, we investigated the mouse dendritic cell (DC) receptor, complement receptor 4 (CR4; CD11c/CD18), as an immunotarget for triggering humoral immunity. Comparison of antibody titres generated against a...
19.
Gray J, French R, James S, Al-Shamkhani A, Johnson P, Glennie M
Eur J Immunol
. 2008 Sep;
38(9):2499-511.
PMID: 18792403
Immunostimulatory mAb as vaccine adjuvants for the treatment of cancer hold considerable potential for boosting weak responses when used against immunogenic tumours, or in combination with various other vaccines. We...
20.
Castro F, Tutt A, White A, Teeling J, James S, French R, et al.
Eur J Immunol
. 2008 Jul;
38(8):2263-73.
PMID: 18651710
The magnitude and quality of T cell responses generated when Ag is targeted to receptors on DC is influenced by both the specific receptor targeted and its distribution among DC...