Sonya G Lehto
Overview
Explore the profile of Sonya G Lehto including associated specialties, affiliations and a list of published articles.
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32
Citations
947
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Recent Articles
1.
McBride H, Frazer-Abel A, Thiemann S, Lehto S, Hutterer K, Liu J
Ann Hematol
. 2023 Oct;
102(12):3299-3309.
PMID: 37817009
ABP 959 is being developed as a biosimilar to Soliris® (eculizumab) reference product (RP), which was approved under orphan designation for a group of rare diseases including paroxysmal nocturnal hemoglobinuria...
2.
Cobb P, Niederwieser D, Cohen S, Hamm C, Burmester G, Seo N, et al.
Immunotherapy
. 2022 May;
14(9):727-740.
PMID: 35543293
ABP 798 (RIABNI™) is a biosimilar to rituximab reference product (RP), a monoclonal antibody that targets CD20. Approval of ABP 798 was based on the totality of evidence generated using...
3.
Hu E, Hong F, Aral J, Long J, Piper D, Poppe L, et al.
J Med Chem
. 2021 Mar;
64(6):3427-3438.
PMID: 33715378
Inhibition of the pituitary adenylate cyclase 1 receptor (PAC1R) is a novel mechanism that could be used for abortive treatment of acute migraine. Our research began with comparative analysis of...
4.
Horne D, Biswas K, Brown J, Bartberger M, Clarine J, Davis C, et al.
J Med Chem
. 2018 Aug;
61(18):8186-8201.
PMID: 30148953
Transient-receptor-potential melastatin 8 (TRPM8), the predominant mammalian cold-temperature thermosensor, is a nonselective cation channel expressed in a subpopulation of sensory neurons in the peripheral nervous system, including nerve circuitry implicated...
5.
Kornecook T, Yin R, Altmann S, Be X, Berry V, Ilch C, et al.
J Pharmacol Exp Ther
. 2017 May;
362(1):146-160.
PMID: 28473457
Potent and selective antagonists of the voltage-gated sodium channel Na1.7 represent a promising avenue for the development of new chronic pain therapies. We generated a small molecule atropisomer quinolone sulfonamide...
6.
Weyer A, Lehto S
Pharmaceuticals (Basel)
. 2017 Mar;
10(2).
PMID: 28358322
A review. Development of pharmaceutical antagonists of transient receptor potential melastatin 8 (TRPM8) have been pursued for the treatment of chronic pain and migraine. This review focuses on the current...
7.
Bregman H, Simard J, Andrews K, Ayube S, Chen H, Gunaydin H, et al.
J Med Chem
. 2016 Dec;
60(3):1105-1125.
PMID: 28001399
Current pain therapeutics suffer from undesirable psychotropic and sedative side effects, as well as abuse potential. Glycine receptors (GlyRs) are inhibitory ligand-gated ion channels expressed in nerves of the spinal...
8.
Huang X, Shaffer P, Ayube S, Bregman H, Chen H, Lehto S, et al.
Nat Struct Mol Biol
. 2016 Dec;
24(2):108-113.
PMID: 27991902
Current therapies to treat persistent pain and neuropathic pain are limited by poor efficacy, side effects and risk of addiction. Here, we present a novel class of potent selective, central...
9.
Lehto S, Weyer A, Youngblood B, Zhang M, Yin R, Wang W, et al.
Mol Pain
. 2016 Dec;
12.
PMID: 27899696
The transient receptor potential ankyrin 1 (TRPA1) channel has been implicated in pathophysiological processes that include asthma, cough, and inflammatory pain. Agonists of TRPA1 such as mustard oil and its...
10.
Schenkel L, Olivieri P, Boezio A, Deak H, Emkey R, Graceffa R, et al.
J Med Chem
. 2016 Mar;
59(6):2794-809.
PMID: 26942860
There has been significant interest in developing a transient receptor potential A1 (TRPA1) antagonist for the treatment of pain due to a wealth of data implicating its role in pain...