Beth D Youngblood
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Explore the profile of Beth D Youngblood including associated specialties, affiliations and a list of published articles.
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10
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125
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Recent Articles
1.
Butler J, Rescourio G, Milgram B, Foti R, Kornecook T, Ligutti J, et al.
Bioorg Med Chem Lett
. 2022 Jul;
73:128892.
PMID: 35850422
Na1.7 is an actively pursued, genetically validated, target for pain. Recently reported quinolinone sulfonamide inhibitors displayed promising selectivity profiles as well as efficacy in preclinical pain models; however, concerns about...
2.
Horne D, Biswas K, Brown J, Bartberger M, Clarine J, Davis C, et al.
J Med Chem
. 2018 Aug;
61(18):8186-8201.
PMID: 30148953
Transient-receptor-potential melastatin 8 (TRPM8), the predominant mammalian cold-temperature thermosensor, is a nonselective cation channel expressed in a subpopulation of sensory neurons in the peripheral nervous system, including nerve circuitry implicated...
3.
Marx I, Dineen T, Able J, Bode C, Bregman H, Chu-Moyer M, et al.
ACS Med Chem Lett
. 2017 Mar;
8(3):378.
PMID: 28337335
[This corrects the article DOI: 10.1021/acsmedchemlett.6b00243.].
4.
Weiss M, Dineen T, Marx I, Altmann S, Boezio A, Bregman H, et al.
J Med Chem
. 2017 Mar;
60(14):5969-5989.
PMID: 28287723
Several reports have recently emerged regarding the identification of heteroarylsulfonamides as Na1.7 inhibitors that demonstrate high levels of selectivity over other Na isoforms. The optimization of a series of internal...
5.
Marx I, Dineen T, Able J, Bode C, Bregman H, Chu-Moyer M, et al.
ACS Med Chem Lett
. 2016 Dec;
7(12):1062-1067.
PMID: 27994738
Human genetic evidence has identified the voltage-gated sodium channel Na1.7 as an attractive target for the treatment of pain. We initially identified naphthalene sulfonamide as a potent and selective inhibitor...
6.
Lehto S, Weyer A, Youngblood B, Zhang M, Yin R, Wang W, et al.
Mol Pain
. 2016 Dec;
12.
PMID: 27899696
The transient receptor potential ankyrin 1 (TRPA1) channel has been implicated in pathophysiological processes that include asthma, cough, and inflammatory pain. Agonists of TRPA1 such as mustard oil and its...
7.
Schenkel L, Olivieri P, Boezio A, Deak H, Emkey R, Graceffa R, et al.
J Med Chem
. 2016 Mar;
59(6):2794-809.
PMID: 26942860
There has been significant interest in developing a transient receptor potential A1 (TRPA1) antagonist for the treatment of pain due to a wealth of data implicating its role in pain...
8.
Lehto S, Weyer A, Zhang M, Youngblood B, Wang J, Wang W, et al.
Naunyn Schmiedebergs Arch Pharmacol
. 2015 Feb;
388(4):465-76.
PMID: 25662185
TRPM8 has been implicated in pain and migraine based on dorsal root- and trigeminal ganglion-enriched expression, upregulation in preclinical models of pain, knockout mouse studies, and human genetics. Here, we...
9.
de Oliveira C, Garami A, Lehto S, Pakai E, Tekus V, Pohoczky K, et al.
J Neurosci
. 2014 Mar;
34(13):4445-52.
PMID: 24671991
The rodent transient receptor potential ankyrin-1 (TRPA1) channel has been hypothesized to serve as a temperature sensor for thermoregulation in the cold. We tested this hypothesis by using deletion of...
10.
Horne D, Tamayo N, Bartberger M, Bo Y, Clarine J, Davis C, et al.
J Med Chem
. 2014 Mar;
57(7):2989-3004.
PMID: 24597733
Transient receptor potential melastatin 8 (TRPM8) is a nonselective cation channel expressed in a subpopulation of sensory neurons in the peripheral nervous system. TRPM8 is the predominant mammalian cold temperature...