Sonja M Wormann
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Explore the profile of Sonja M Wormann including associated specialties, affiliations and a list of published articles.
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8
Citations
443
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Recent Articles
1.
Rupani D, Thege F, Chandra V, Rajaei H, Cowan R, Wormann S, et al.
Development
. 2022 Dec;
150(2).
PMID: 36458554
Adenosine deaminase acting on RNA 1 (ADAR1) is an RNA-binding protein that deaminates adenosine (A) to inosine (I). A-to-I editing alters post-transcriptional RNA processing, making ADAR1 a crucial regulator of...
2.
Thege F, Rupani D, Barathi B, Manning S, Maitra A, Rhim A, et al.
Cancer Res
. 2022 Jun;
82(15):2761-2776.
PMID: 35666804
Significance: A streamlined platform for programmable CRISPR gene activation enables rapid evaluation and functional validation of putative oncogenes in vivo.
3.
Wormann S, Zhang A, Thege F, Cowan R, Rupani D, Wang R, et al.
Nat Cancer
. 2022 Feb;
2(12):1338-1356.
PMID: 35121902
Despite efforts in understanding its underlying mechanisms, the etiology of chromosomal instability (CIN) remains unclear for many tumor types. Here, we identify CIN initiation as a previously undescribed function for...
4.
Ai J, Wormann S, Gorgulu K, Vallespinos M, Zagorac S, Alcala S, et al.
Gastroenterology
. 2021 Apr;
161(1):318-332.e9.
PMID: 33819482
Background & Aims: The existence of different subtypes of pancreatic ductal adenocarcinoma (PDAC) and their correlation with patient outcome have shifted the emphasis on patient classification for better decision-making algorithms...
5.
Gorgulu K, Diakopoulos K, Ai J, Schoeps B, Kabacaoglu D, Karpathaki A, et al.
Gastroenterology
. 2018 Oct;
156(1):203-217.e20.
PMID: 30296435
Background And Aims: Cells in pancreatic ductal adenocarcinoma (PDAC) undergo autophagy, but its effects vary with tumor stage and genetic factors. We investigated the consequences of varying levels of the...
6.
Ruess D, Heynen G, Ciecielski K, Ai J, Berninger A, Kabacaoglu D, et al.
Nat Med
. 2018 May;
24(7):954-960.
PMID: 29808009
The ubiquitously expressed non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, is involved in signal transduction downstream of multiple growth factor, cytokine and integrin receptors. Its requirement for complete RAS-MAPK...
7.
Ruess D, Gorgulu K, Wormann S, Algul H
Drugs Aging
. 2017 Mar;
34(5):331-357.
PMID: 28349415
Pancreatic ductal adenocarcinoma is a devastating malignancy, which is the result of late diagnosis, aggressive disease, and a lack of effective treatment options. Thus, pancreatic ductal adenocarcinoma is projected to...
8.
Wormann S, Song L, Ai J, Diakopoulos K, Kurkowski M, Gorgulu K, et al.
Gastroenterology
. 2016 Mar;
151(1):180-193.e12.
PMID: 27003603
Background & Aims: One treatment strategy for pancreatic ductal adenocarcinoma is to modify, rather than deplete, the tumor stroma. Constitutive activation of the signal transducer and activator of transcription 3...