Somesh Mohapatra
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Explore the profile of Somesh Mohapatra including associated specialties, affiliations and a list of published articles.
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11
Citations
67
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Recent Articles
1.
Truex N, Mohapatra S, Melo M, Rodriguez J, Li N, Abraham W, et al.
ACS Cent Sci
. 2024 Apr;
10(4):793-802.
PMID: 38680558
Antigen processing is critical for therapeutic vaccines to generate epitopes for priming cytotoxic T cell responses against cancer and pathogens, but insufficient processing often limits the quantity of epitopes released....
2.
Singh K, Maurya H, Singh P, Panda P, Behera A, Jamal A, et al.
Database (Oxford)
. 2023 Oct;
2023.
PMID: 37847815
Medicinal plants are anticipated to be one of the most valuable resources for the remedial usage in the treatment of various ailments. The data on key medicinal plants and their...
3.
Alfaraj Y, Mohapatra S, Shieh P, Husted K, Ivanoff D, Lloyd E, et al.
ACS Cent Sci
. 2023 Oct;
9(9):1810-1819.
PMID: 37780353
Thermosets present sustainability challenges that could potentially be addressed through the design of deconstructable variants with tunable properties; however, the combinatorial space of possible thermoset molecular building blocks (e.g., monomers,...
4.
Truex N, Mohapatra S, Melo M, Rodriguez J, Li N, Abraham W, et al.
bioRxiv
. 2023 Sep;
PMID: 37662211
Antigen processing is critical for producing epitope peptides that are presented by HLA molecules for T cell recognition. Therapeutic vaccines aim to harness these epitopes for priming cytotoxic T cell...
5.
Li C, Zhang G, Mohapatra S, Callahan A, Loas A, Gomez-Bombarelli R, et al.
Adv Sci (Weinh)
. 2022 Oct;
9(34):e2201988.
PMID: 36270977
Peptide nucleic acids (PNAs) are potential antisense therapies for genetic, acquired, and viral diseases. Efficiently selecting candidate PNA sequences for synthesis and evaluation from a genome containing hundreds to thousands...
6.
Lopez-Vidal E, Schissel C, Mohapatra S, Bellovoda K, Wu C, Wood J, et al.
JACS Au
. 2021 Nov;
1(11):2009-2020.
PMID: 34841414
Therapeutic macromolecules such as proteins and oligonucleotides can be highly efficacious but are often limited to extracellular targets due to the cell's impermeable membrane. Cell-penetrating peptides (CPPs) are able to...
7.
Nguyen H, Jiang Y, Mohapatra S, Wang W, Barnes J, Oldenhuis N, et al.
Nat Chem
. 2021 Nov;
14(1):85-93.
PMID: 34824461
Chirality and molecular conformation are central components of life: biological systems rely on stereospecific interactions between discrete (macro)molecular conformers, and the impacts of stereochemistry and rigidity on the properties of...
8.
Hartweg M, Jiang Y, Yilmaz G, Jarvis C, Nguyen H, Primo G, et al.
JACS Au
. 2021 Nov;
1(10):1621-1630.
PMID: 34723265
Carbohydrate-binding proteins (lectins) play vital roles in cell recognition and signaling, including pathogen binding and innate immunity. Thus, targeting lectins, especially those on the surface of immune cells, could advance...
9.
Schissel C, Mohapatra S, Wolfe J, Fadzen C, Bellovoda K, Wu C, et al.
Nat Chem
. 2021 Aug;
13(10):992-1000.
PMID: 34373596
There are more amino acid permutations within a 40-residue sequence than atoms on Earth. This vast chemical search space hinders the use of human learning to design functional polymers. Here...
10.
Mohapatra S, Hartrampf N, Poskus M, Loas A, Gomez-Bombarelli R, Pentelute B
ACS Cent Sci
. 2020 Dec;
6(12):2277-2286.
PMID: 33376788
The chemical synthesis of polypeptides involves stepwise formation of amide bonds on an immobilized solid support. The high yields required for efficient incorporation of each individual amino acid in the...