Sohrab Salehi
Overview
Explore the profile of Sohrab Salehi including associated specialties, affiliations and a list of published articles.
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Articles
16
Citations
192
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0
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Recent Articles
1.
Weiner A, Williams M, Shi H, Vazquez-Garcia I, Salehi S, Rusk N, et al.
Nat Commun
. 2024 Oct;
15(1):8512.
PMID: 39353885
Dysregulated DNA replication is a cause and a consequence of aneuploidy in cancer, yet the interplay between copy number alterations (CNAs), replication timing (RT) and cell cycle dynamics remain understudied...
2.
Quintanal-Villalonga A, Kawasaki K, Redin E, Uddin F, Rakhade S, Durani V, et al.
Signal Transduct Target Ther
. 2024 Jul;
9(1):189.
PMID: 39054323
Neuroendocrine (NE) transformation is a mechanism of resistance to targeted therapy in lung and prostate adenocarcinomas leading to poor prognosis. Up to date, even if patients at high risk of...
3.
Kabeer F, Tran H, Andronescu M, Singh G, Lee H, Salehi S, et al.
Genome Biol
. 2024 Jul;
25(1):191.
PMID: 39026273
Background: The encoding of cell intrinsic drug resistance states in breast cancer reflects the contributions of genomic and non-genomic variations and requires accurate estimation of clonal fitness from co-measurement of...
4.
Kim M, Gorelick A, Vazquez-Garcia I, Williams M, Salehi S, Shi H, et al.
Nat Genet
. 2024 May;
56(5):889-899.
PMID: 38741018
The extent of cell-to-cell variation in tumor mitochondrial DNA (mtDNA) copy number and genotype, and the phenotypic and evolutionary consequences of such variation, are poorly characterized. Here we use amplification-free...
5.
Salehi S, Schallmayer E, Bandomir N, Karcher A, Guth J, Heitel P
Arch Pharm (Weinheim)
. 2024 Mar;
357(7):e2300756.
PMID: 38501877
The nuclear receptors hepatocyte nuclear factor 4α (HNF4α) and retinoic acid receptor-related orphan receptor-β (RORβ) are ligand-regulated transcription factors and potential drug targets for metabolic disorders. However, there is a...
6.
Ceglia N, Sethna Z, Freeman S, Uhlitz F, Bojilova V, Rusk N, et al.
Nat Commun
. 2023 Jul;
14(1):4400.
PMID: 37474509
Deciphering individual cell phenotypes from cell-specific transcriptional processes requires high dimensional single cell RNA sequencing. However, current dimensionality reduction methods aggregate sparse gene information across cells, without directly measuring the...
7.
Weiner A, Williams M, Shi H, Vazquez-Garcia I, Salehi S, Rusk N, et al.
bioRxiv
. 2023 Apr;
PMID: 37090647
Dysregulated DNA replication is both a cause and a consequence of aneuploidy, yet the dynamics of DNA replication in aneuploid cell populations remains understudied. We developed a new method, PERT,...
8.
Funnell T, OFlanagan C, Williams M, McPherson A, McKinney S, Kabeer F, et al.
Nature
. 2022 Oct;
612(7938):106-115.
PMID: 36289342
How cell-to-cell copy number alterations that underpin genomic instability in human cancers drive genomic and phenotypic variation, and consequently the evolution of cancer, remains understudied. Here, by applying scaled single-cell...
9.
Eirew P, OFlanagan C, Ting J, Salehi S, Brimhall J, Wang B, et al.
Nat Commun
. 2022 Aug;
13(1):4534.
PMID: 35927228
Assessing tumour gene fitness in physiologically-relevant model systems is challenging due to biological features of in vivo tumour regeneration, including extreme variations in single cell lineage progeny. Here we develop...
10.
Karami A, Javadi A, Salehi S, Nasirian N, Maali A, Bakhshalizadeh Shadkam M, et al.
Iran J Microbiol
. 2022 Jun;
14(2):161-167.
PMID: 35765546
Background And Objectives: Prostatitis affects about 16% of men in their lifetime and sometimes leading to prostate cancer. Bacterial infections are the most common causes of prostatitis. Diagnosis of the...