Sofie Mossner
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Explore the profile of Sofie Mossner including associated specialties, affiliations and a list of published articles.
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8
Citations
33
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Recent Articles
1.
Baumgartner L, Ettich J, Balles H, Lapp D, Mossner S, Bassenge C, et al.
Biol Chem
. 2024 May;
405(7-8):531-544.
PMID: 38695485
Naturally occurring gain-of-function (GOF) mutants have been identified in patients for a variety of cytokine receptors. Although this constitutive activation of cytokine receptors is strongly associated with malignant disorders, ligand-independent...
2.
Minafra A, Rafii P, Mossner S, Bazgir F, Floss D, Moll J, et al.
J Biol Chem
. 2023 Jul;
299(8):104989.
PMID: 37392849
Synthetic biology has emerged as a useful technology for studying cytokine signal transduction. Recently, we described fully synthetic cytokine receptors to phenocopy trimeric receptors such as the death receptor Fas/CD95....
3.
Zoellner N, Coesfeld N, De Vos F, Denter J, Xu H, Zimmer E, et al.
Front Microbiol
. 2022 Sep;
13:947169.
PMID: 36118237
Type I interferons (IFNs) are potent inhibitors of viral replication. Here, we reformatted the natural murine and human type I interferon-α/β receptors IFNAR1 and IFNAR2 into fully synthetic biological switches....
4.
Mossner S, Floss D, Scheller J
iScience
. 2021 Jun;
24(5):102471.
PMID: 34113818
Synthetic strategies to activate cytokine receptors so far only address standard dimeric cytokine receptor assemblies. The 19 ligands of the tumor necrosis factor superfamily (TNFSF), however, form noncovalent trimers and...
5.
Mossner S, Phan H, Triller S, Moll J, Conrad U, Scheller J
PLoS One
. 2020 Sep;
15(9):e0238925.
PMID: 32881955
[This corrects the article DOI: 10.1371/journal.pone.0230804.].
6.
Mossner S, Kuchner M, Modares N, Knebel B, Al-Hasani H, Floss D, et al.
J Biol Chem
. 2020 Jul;
295(35):12378-12397.
PMID: 32611765
Cytokine signaling is transmitted by cell-surface receptors that function as biological switches controlling mainly immune-related processes. Recently, we have designed synthetic cytokine receptors (SyCyRs) consisting of GFP and mCherry nanobodies...
7.
Esch A, Masiarz A, Mossner S, Moll J, Grotzinger J, Schroder J, et al.
J Biol Chem
. 2020 Jun;
295(30):10478-10492.
PMID: 32518162
Interleukin (IL)-12 and IL-23 belong to the IL-12 type family and are composite cytokines, consisting of the common β subunit p40 and the specific cytokine α subunit p35 and p19,...
8.
Mossner S, Phan H, Triller S, Moll J, Conrad U, Scheller J
PLoS One
. 2020 Apr;
15(4):e0230804.
PMID: 32236103
Cytokine signaling is transmitted by cell surface receptors which act as natural biological switches to control cellular functions such as immune reactions. Recently, we have designed synthetic cytokine receptors (SyCyRs)...