Sita D Gupta
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Explore the profile of Sita D Gupta including associated specialties, affiliations and a list of published articles.
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19
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590
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Recent Articles
1.
Xie T, Dong F, Han G, Wu X, Liu P, Zhang Z, et al.
Cell Rep
. 2024 Jan;
43(2):113717.
PMID: 38285738
The homeostatic regulation of serine palmitoyltransferase (SPT) activity in yeast involves N-terminal phosphorylation of Orm proteins, while higher eukaryotes lack these phosphorylation sites. Although recent studies have indicated a conserved...
2.
Syeda S, Lone M, Mohassel P, Donkervoort S, Munot P, Franca Jr M, et al.
J Neurol Neurosurg Psychiatry
. 2023 Dec;
95(2):103-113.
PMID: 38041679
Background: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the upper and lower motor neurons with varying ages of onset, progression and pathomechanisms. Monogenic childhood-onset ALS, although rare, forms...
3.
Liu P, Xie T, Wu X, Han G, Gupta S, Zhang Z, et al.
Sci Adv
. 2023 Mar;
9(13):eadg0728.
PMID: 36989369
The serine palmitoyltransferase (SPT) complex catalyzes the first and rate-limiting step in sphingolipid biosynthesis in all eukaryotes. ORM/ORMDL proteins are negative regulators of SPT that respond to cellular sphingolipid levels....
4.
Srivastava S, Shaked H, Gable K, Gupta S, Pan X, Somashekarappa N, et al.
Brain
. 2023 Jan;
146(4):1420-1435.
PMID: 36718090
Sphingolipids are a diverse family of lipids with critical structural and signalling functions in the mammalian nervous system, where they are abundant in myelin membranes. Serine palmitoyltransferase, the enzyme that...
5.
Fiorillo C, Capodivento G, Geroldi A, Tozza S, Moroni I, Mohassel P, et al.
Neuropathol Appl Neurobiol
. 2022 Jul;
48(7):e12842.
PMID: 35904184
Aims: SPTLC1-related disorder is a late onset sensory-autonomic neuropathy associated with perturbed sphingolipid homeostasis which can be improved by supplementation with the serine palmitoyl-CoA transferase (SPT) substrate, l-serine. Recently, a...
6.
Mohassel P, Donkervoort S, Lone M, Nalls M, Gable K, Gupta S, et al.
Nat Med
. 2021 Jun;
27(7):1197-1204.
PMID: 34059824
Amyotrophic lateral sclerosis (ALS) is a progressive, neurodegenerative disease of the lower and upper motor neurons with sporadic or hereditary occurrence. Age of onset, pattern of motor neuron degeneration and...
7.
Wang Y, Niu Y, Zhang Z, Gable K, Gupta S, Somashekarappa N, et al.
Nat Struct Mol Biol
. 2021 Feb;
28(3):240-248.
PMID: 33558761
Sphingolipids are essential lipids in eukaryotic membranes. In humans, the first and rate-limiting step of sphingolipid synthesis is catalyzed by the serine palmitoyltransferase holocomplex, which consists of catalytic components (SPTLC1...
8.
Han G, Gupta S, Gable K, Bacikova D, Sengupta N, Somashekarappa N, et al.
Biochim Biophys Acta Mol Cell Biol Lipids
. 2018 Dec;
1864(3):245-259.
PMID: 30529276
Serine palmitoyltransferase (SPT), an endoplasmic reticulum-localized membrane enzymecomposed of acatalytic LCB1/LCB2 heterodimer and a small activating subunit (Tsc3 in yeast; ssSPTs in mammals), is negatively regulated by the evolutionarily conserved...
9.
Zhao L, Spassieva S, Gable K, Gupta S, Shi L, Wang J, et al.
Proc Natl Acad Sci U S A
. 2015 Oct;
112(42):12962-7.
PMID: 26438849
Sphingolipids typically have an 18-carbon (C18) sphingoid long chain base (LCB) backbone. Although sphingolipids with LCBs of other chain lengths have been identified, the functional significance of these low-abundance sphingolipids...
10.
Gupta S, Gable K, Alexaki A, Chandris P, Proia R, Dunn T, et al.
J Biol Chem
. 2014 Nov;
290(1):90-8.
PMID: 25395622
The relationship between serine palmitoyltransferase (SPT) activity and ORMDL regulation of sphingolipid biosynthesis was investigated in mammalian HEK293 cells. Each of the three human ORMDLs reduced the increase in long-chain...