Sirisha Mukkavalli
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Explore the profile of Sirisha Mukkavalli including associated specialties, affiliations and a list of published articles.
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7
Citations
69
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Recent Articles
1.
Li F, Zhang T, Syed A, Elbakry A, Holmer N, Nguyen H, et al.
Nat Commun
. 2025 Feb;
16(1):1714.
PMID: 39962076
The CHAMP1 complex, a little-known but highly conserved protein complex consisting of CHAMP1, POGZ, and HP1α, is enriched in heterochromatin though its cellular function in these regions of the genome...
2.
Ravindranathan R, Somuncu O, da Costa A, Mukkavalli S, Lamarre B, Nguyen H, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(47):e2413954121.
PMID: 39546575
Poly (ADP-ribose) glycohydrolase (PARG) is a dePARylating enzyme which promotes DNA repair by removal of poly (ADP-ribose) (PAR) from PARylated proteins. Loss or inhibition of PARG results in replication stress...
3.
da Costa A, Somuncu O, Ravindranathan R, Mukkavalli S, Martignetti D, Nguyen H, et al.
Cancer Res
. 2024 Jun;
84(20):3435-3446.
PMID: 38885312
Recent studies suggest that PARP and POLQ inhibitors confer synthetic lethality in BRCA1-deficient tumors by accumulation of single-stranded DNA (ssDNA) gaps at replication forks. Loss of USP1, a deubiquitinating enzyme,...
4.
Ahlstedt B, Ganji R, Mukkavalli S, Paulo J, Gygi S, Raman M
EMBO Rep
. 2024 Jan;
25(2):672-703.
PMID: 38177917
ER protein homeostasis (proteostasis) is essential for proper folding and maturation of proteins in the secretory pathway. Loss of ER proteostasis can lead to the accumulation of misfolded or aberrant...
5.
Kochenova O, Mukkavalli S, Raman M, Walter J
Nat Commun
. 2022 Nov;
13(1):6591.
PMID: 36329031
The p97 ATPase extracts polyubiquitylated proteins from diverse cellular structures in preparation for destruction by the proteasome. p97 functions with Ufd1-Npl4 and a variety of UBA-UBX co-factors, but how p97...
6.
Mukkavalli S, Klickstein J, Ortiz B, Juo P, Raman M
J Cell Sci
. 2021 Mar;
134(7).
PMID: 33712450
The recognition and disposal of misfolded proteins is essential for the maintenance of cellular homeostasis. Perturbations in the pathways that promote degradation of aberrant proteins contribute to a variety of...
7.
Klickstein J, Mukkavalli S, Raman M
J Biol Chem
. 2021 Jan;
295(51):17672-17683.
PMID: 33454006
Protein quality control is maintained by a number of integrated cellular pathways that monitor the folding and functionality of the cellular proteome. Defects in these pathways lead to the accumulation...
8.
Ganji R, Mukkavalli S, Somanji F, Raman M
Mol Cell Biol
. 2018 Apr;
38(13).
PMID: 29685906
A balance between protein synthesis and degradation is necessary to maintain cellular homeostasis. Failure to triage aberrant proteins may result in their accumulation and aggregation in the cytosol. The valosin-containing...