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Sin Man Lam

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Articles 138
Citations 2576
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Recent Articles
1.
Chen J, Xiang J, Zhou M, Huang R, Zhang J, Cui Y, et al.
Cell Metab . 2025 Mar; PMID: 40088888
Feeding rhythms regulate exercise performance and muscle energy metabolism. However, the mechanisms regulating adipocyte functions remain unclear. Here, using multi-omics analyses, involving (phospho-)proteomics and lipidomics, we found that day-restricted feeding...
2.
Lai P, Miao G, Zhao Y, Han Y, Li Y, Liu Y, et al.
Nat Commun . 2025 Mar; 16(1):2430. PMID: 40069146
Scavenger receptor class A member 3 (SR-A3) is implicated in metabolic diseases; however, the relationship between SR-A3 and metabolic dysfunction-associated fatty liver disease (MAFLD) has not been documented. Here, we...
3.
Zhang W, Guo J, Miao G, Chen J, Xu Y, Lai P, et al.
Research (Wash D C) . 2025 Mar; 8:0577. PMID: 40052160
Fat-1, an enzyme encoded by the gene, is responsible for the conversion of endogenous omega-6 polyunsaturated fatty acids into omega-3 polyunsaturated fatty acids in . To better investigate whether the...
4.
Xing L, Wu S, Shi Y, Wei L, Yue F, Lam S, et al.
J Pharmacol Exp Ther . 2025 Feb; 392(3):103388. PMID: 39921942
Obesity-related kidney disease (ORKD) has recently become a global health issue. Metformin is widely used in patients with type 2 diabetes with concomitant obesity, but its effects on ORKD are...
5.
Wan L, Lam S, Huang H, Cao W, Cao X, Li X, et al.
J Transl Med . 2025 Jan; 23(1):143. PMID: 39891216
Background: Despite the success of antiretroviral therapy (ART) in suppressing HIV-1 replication, some people living with HIV-1 (PLWH) fail to achieve an optimal recovery of CD4 T cells, and precise...
6.
Qu Q, Chen Y, Wang Y, Long S, Wang W, Yang H, et al.
Nature . 2025 Jan; 638(8050):E6. PMID: 39875609
No abstract available.
7.
Zhu J, Lam S, Yang L, Liang J, Ding M, Shui G, et al.
Life Metab . 2025 Jan; 1(2):175-189. PMID: 39872351
Seipin plays a vital role in lipid droplet homeostasis, and its deficiency causes congenital generalized lipodystrophy type II in humans. It is not known whether the physiological defects are all...
8.
Li J, Dong Y, Zhou T, Tian H, Huang X, Zhang Y, et al.
Life Metab . 2025 Jan; 3(2):loae004. PMID: 39872215
Interorgan lipid transport is crucial for organism development and the maintenance of physiological function. Here, we demonstrate that long-chain acyl-CoA synthetase (dAcsl), which catalyzes the conversion of fatty acids into...
9.
Dong Y, Su L, Lam S, Yan C, Deng Y, Lu G, et al.
Sci China Life Sci . 2025 Jan; PMID: 39821836
No abstract available.
10.
Qu Q, Chen Y, Wang Y, Long S, Wang W, Yang H, et al.
Nature . 2024 Dec; PMID: 39695227
Calorie restriction (CR) is a dietary intervention used to promote health and longevity. CR causes various metabolic changes in both the production and the circulation of metabolites; however, it remains...