Sin-Jin Li
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Explore the profile of Sin-Jin Li including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
125
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Recent Articles
1.
Yang W, Chang P, Li S, Ding S, Lin Y
Animals (Basel)
. 2024 Apr;
14(7).
PMID: 38612231
Excessive liver fat causes non-alcoholic fatty liver disease (NAFLD) in laying hens, reducing egg production. Addressing NAFLD via bile-acid metabolism is gaining attention. We induced NAFLD in 7-week-old ISA female...
2.
Rios L, Pokhrel S, Li S, Heo G, Haileselassie B, Mochly-Rosen D
Nat Commun
. 2023 Jul;
14(1):4356.
PMID: 37468472
The large cytosolic GTPase, dynamin-related protein 1 (Drp1), mediates both physiological and pathological mitochondrial fission. Cell stress triggers Drp1 binding to mitochondrial Fis1 and subsequently, mitochondrial fragmentation, ROS production, metabolic...
3.
Mukherjee R, Tetri L, Li S, Fajardo G, Ostberg N, Tsegay K, et al.
J Mol Cell Cardiol
. 2023 Feb;
177:28-37.
PMID: 36841153
Background: Previous studies have implicated p53-dependent mitochondrial dysfunction in sepsis induced end organ injury, including sepsis-induced myocardial dysfunction (SIMD). However, the mechanisms behind p53 localization to the mitochondria have not...
4.
Chiang C, Li S, Lin Y, Wang P, Hsu P, Lin S, et al.
Biogerontology
. 2023 Feb;
24(3):391-401.
PMID: 36802043
Non-alcoholic fatty liver disease is associated with ageing, and impaired mitochondrial homeostasis is the main cause for hepatic ageing. Caloric restriction (CR) is a promising therapeutic approach for fatty liver....
5.
Chiang C, Li S, Zhang T, Chen C
Biogerontology
. 2022 Oct;
23(6):731-740.
PMID: 36183304
As the kidneys age, gradual changes in the structures and functions of mitochondria occur. Dietary restriction (DR) can play a protective role in ageing-associated renal decline, however the exact mechanisms...
6.
Greenberg D, Bhambhvani H, Basran S, Salazar B, Rios L, Li S, et al.
J Urol
. 2022 Mar;
208(2):406-413.
PMID: 35344413
Purpose: Inactivating mutations in mitochondrial aldehyde dehydrogenase 2 (ALDH2) are highly prevalent. The most common variant allele, , is present in 40%-50% of East Asians, and causes acetaldehyde accumulation, flushing...
7.
Li S, Lin Y, Chiang C, Wang P, Chen C
J Nutr Biochem
. 2022 Jan;
101:108944.
PMID: 35017002
Dietary restriction (DR) exerts healthy benefits, including heart functions. However, the cardioprotective role of DR is till controversial among researchers due to the variation of DR conditions. The present study...
8.
Chien M, Li S, Wong S, Chiang C, Lin Y, Mersmann H, et al.
Arch Physiol Biochem
. 2021 Aug;
129(6):1289-1297.
PMID: 34338085
The purpose of this study was to investigate the nexus between mitochondrial function and kidney injury by using a dietary-induced obese minipig model. Female Lee-Sung minipigs feeding a high-fat diet...
9.
Chen C, Ferreira J, Joshi A, Stevens M, Li S, Hsu J, et al.
EBioMedicine
. 2020 May;
55:102753.
PMID: 32403082
Background: Aldehyde dehydrogenase 2 (ALDH2) catalyzes the detoxification of aliphatic aldehydes, including acetaldehyde. About 45% of Han Chinese (East Asians), accounting for 8% of humans, carry a single point mutation...
10.
Chen C, Li S, Wang C, Mersmann H, Ding S
Eur J Clin Invest
. 2020 Jan;
50(3):e13204.
PMID: 31990365
Background: The heart is a highly oxidative tissue, thus mitochondria play a major role in maintaining optimal cardiac function. Our previous study established a dietary-induced obese minipig with cardiac fibrosis....