Simone P Zehntner
Overview
Explore the profile of Simone P Zehntner including associated specialties, affiliations and a list of published articles.
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17
Citations
918
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Recent Articles
1.
Tambini M, Yin T, Yesiltepe M, Breuillaud L, Zehntner S, dAbramo C, et al.
J Biol Chem
. 2023 May;
299(7):104868.
PMID: 37257821
About 2% of Alzheimer's disease (AD) cases have early onset (FAD) and are caused by mutations in either Presenilins (PSEN1/2) or amyloid-β precursor protein (APP). PSEN1/2 catalyze production of Aβ...
2.
Yesiltepe M, Yin T, Tambini M, Breuillaud L, Zehntner S, DAdamio L
Front Aging Neurosci
. 2022 Nov;
14:1040576.
PMID: 36438008
Cleavage of Amyloid precursor protein by β- and γ-secretases lead to Aβ formation. The widely accepted pathogenic model states that these mutations cause AD via an increase in Aβ formation...
3.
Ren S, Breuillaud L, Yao W, Yin T, Norris K, Zehntner S, et al.
J Biol Chem
. 2021 Jan;
296:100089.
PMID: 33434745
Alzheimer's disease (AD) is a neurodegenerative dementia associated with deposition of amyloid plaques and neurofibrillary tangles, formed by amyloid β (Aβ) peptides and phosphor-tau, respectively, in the central nervous system....
4.
Dugger B, Clark C, Serrano G, Mariner M, Bedell B, Coleman R, et al.
J Neuropathol Exp Neurol
. 2013 Dec;
73(1):72-80.
PMID: 24335535
Neuropathologic heterogeneity is often present among Alzheimer disease (AD) patients. We sought to determine whether amyloid imaging measures of AD are affected by concurrent pathologies. Thirty-eight clinically and pathologically defined...
5.
GrandMaison M, Zehntner S, Ho M, Hebert F, Wood A, Carbonell F, et al.
Neurobiol Dis
. 2013 Mar;
54:59-67.
PMID: 23454197
Magnetic resonance imaging (MRI) studies have identified aberrant cortical structure in Alzheimer's disease (AD). The association between MRI-derived cortical morphometry measures and β-amyloid, however, remains poorly understood. In this study,...
6.
Choi S, Schneider J, Bennett D, Beach T, Bedell B, Zehntner S, et al.
Alzheimer Dis Assoc Disord
. 2012 Feb;
26(1):8-16.
PMID: 22354138
Background: Florbetapir F 18 (F-AV-45) is a positron emission tomography imaging ligand for the detection of amyloid aggregation associated with Alzheimer disease. Earlier data showed that florbetapir F 18 binds...
7.
Clark C, Schneider J, Bedell B, Beach T, Bilker W, Mintun M, et al.
JAMA
. 2011 Jan;
305(3):275-83.
PMID: 21245183
Context: The ability to identify and quantify brain β-amyloid could increase the accuracy of a clinical diagnosis of Alzheimer disease. Objective: To determine if florbetapir F 18 positron emission tomographic...
8.
Miron V, Zehntner S, Kuhlmann T, Ludwin S, Owens T, Kennedy T, et al.
Am J Pathol
. 2009 Apr;
174(5):1880-90.
PMID: 19349355
Remyelination of lesions in the central nervous system contributes to neural repair following clinical relapses in multiple sclerosis. Remyelination is initiated by recruitment and differentiation of oligodendrocyte progenitor cells (OPCs)...
9.
Zehntner S, Chakravarty M, Bolovan R, Chan C, Bedell B
J Histochem Cytochem
. 2008 Jun;
56(10):873-80.
PMID: 18574255
Quantitative analysis of digitized IHC-stained tissue sections is increasingly used in research studies and clinical practice. Accurate quantification of IHC staining, however, is often complicated by conventional tissue counterstains caused...
10.
Zehntner S, Bourbonniere L, Moore C, Morris S, Methot D, St Jean M, et al.
J Immunol
. 2007 Nov;
179(11):7553-60.
PMID: 18025200
To understand how the balance between pro- and anti-apoptotic signals influences effector function in the immune system, we studied the X-linked inhibitor of apoptosis (XIAP), an endogenous regulator of cellular...