Simone Benitz
Overview
Explore the profile of Simone Benitz including associated specialties, affiliations and a list of published articles.
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13
Citations
88
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Recent Articles
1.
Salas-Escabillas D, Hoffman M, Brender S, Moore J, Wen H, Benitz S, et al.
Dev Cell
. 2024 Dec;
PMID: 39721583
Pancreatic ductal adenocarcinoma (PDA) is partly initiated through the transdifferentiation of acinar cells to metaplasia, which progresses to neoplasia and cancer. Tuft cells (TCs) are chemosensory cells not found in...
2.
Benitz S, Steep A, Nasser M, Preall J, Mahajan U, McQuithey H, et al.
Cancer Discov
. 2024 Jul;
14(11):2162-2182.
PMID: 38975886
Cellular plasticity is a hallmark of pancreatic ductal adenocarcinoma (PDAC) starting from the conversion of normal cells into precancerous lesions, to the progression of carcinoma subtypes associated with aggressiveness and...
3.
Salas-Escabillas D, Hoffman M, Moore J, Brender S, Wen H, Benitz S, et al.
bioRxiv
. 2024 Feb;
PMID: 38405804
Pancreatic ductal adenocarcinoma (PDA) is partly initiated through the transdifferentiation of acinar cells to metaplastic ducts that act as precursors of neoplasia and cancer. Tuft cells are solitary chemosensory cells...
4.
Zhou Q, Pichlmeier S, Denz A, Schreiner N, Straub T, Benitz S, et al.
Int J Oncol
. 2024 Jan;
64(3).
PMID: 38240084
Pancreatic ductal adenocarcinoma (PDAC) is often diagnosed at advanced tumor stages with chemotherapy as the only treatment option. Transcriptomic analysis has defined a classical and basal‑like PDAC subtype, which are...
5.
Benitz S, Steep A, Nasser M, Preall J, Mahajan U, McQuithey H, et al.
bioRxiv
. 2024 Jan;
PMID: 38168289
Cellular plasticity is a hallmark of pancreatic ductal adenocarcinoma (PDAC) starting from the conversion of normal cells into precancerous lesions to the progression of carcinoma subtypes associated with aggressiveness and...
6.
7.
Hoffman M, Kemp S, Salas-Escabillas D, Zhang Y, Steele N, The S, et al.
Cell Mol Gastroenterol Hepatol
. 2020 Sep;
11(2):349-369.
PMID: 32882403
Background & Aims: Pancreatic ductal adenocarcinoma (PDA) initiation and progression are accompanied by an immunosuppressive inflammatory response. Here, we evaluated the immunomodulatory role of chemosensory signaling in metaplastic tuft cells...
8.
Regel I, Eichenmuller M, Mahajan U, Hagl B, Benitz S, Haberle B, et al.
J Cancer Res Clin Oncol
. 2020 Mar;
146(5):1153-1167.
PMID: 32189106
Background: Hepatoblastoma (HB) and pediatric hepatocellular carcinoma (HCC) are the most common malignant liver tumors in childhood. Both tumor types exhibit genetic and epigenetic alterations in the WNT/β-catenin signaling pathway,...
9.
Benitz S, Straub T, Mahajan U, Mutter J, Czemmel S, Unruh T, et al.
Gut
. 2019 Apr;
68(11):2007-2018.
PMID: 30954952
Background And Aims: Besides well-defined genetic alterations, the dedifferentiation of mature acinar cells is an important prerequisite for pancreatic carcinogenesis. Acinar-specific genes controlling cell homeostasis are extensively downregulated during cancer...
10.
Regel I, Raulefs S, Benitz S, Mihaljevic C, Rieder S, Leinenkugel G, et al.
Pancreatology
. 2018 Dec;
19(1):149-157.
PMID: 30583980
Background: Acute pancreatitis is accompanied by acinar cell damage releasing potential toll-like receptor 3 (TLR3) ligands. So far, TLR3 is known as a pattern recognition receptor in the immune signaling...