Gene-Environment Interaction in a Conditional NMDAR-Knockout Model of Schizophrenia

Overview

Journal Front Behav Neurosci

Specialty Psychology

Date 2019 Jan 29

PMID 30687034

Citations 5

Authors

Alexei M Bygrave

Simonas Masiulis

Dimitri M Kullmann

David M Bannerman

Dennis Katzel

Affiliations

Soon will be listed here.

Abstract

Interactions between genetic and environmental risk factors take center stage in the pathology of schizophrenia. We assessed if the stressor of reduced environmental enrichment applied in adulthood provokes deficits in the positive, negative or cognitive symptom domains of schizophrenia in a mouse line modeling NMDA-receptor (NMDAR) hypofunction in forebrain inhibitory interneurons ( ). We find that mice, when group-housed in highly enriched cages, appear largely normal across a wide range of schizophrenia-related behavioral tests. However, they display various short-term memory deficits when exposed to minimal enrichment. This demonstrates that the interaction between risk genes causing NMDA-receptor hypofunction and environmental risk factors may negatively impact cognition later in life.

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